Micronutrient Deficiency Syndrome: Zinc, Copper and Selenium

Lee, Jee Hyun

doi:10.5223/pghn.2012.15.3.145

Cited by 5 publications

(5 citation statements)

References 36 publications

(37 reference statements)

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“…Second, the number of types of trace elements analyzed in this study is limited. There are difficulties in measuring the concentration and insufficiency of micronutrients in the body [ 22 ]. In this study, various micronutrients were analyzed in comparison with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Micronutrients Are Not Deficient in Children with Nonorganic Failure to Thrive

Hong

Park

Kang

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

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PurposeInadequate calorie intake is one of the most important causes of nonorganic failure to thrive (NOFTT) and is thought to lead to multiple micronutrient deficiencies. However, there have been few studies on NOFTT and micronutrients. The aim of this study was to evaluate the micronutrient status of children with NOFTT.MethodsWe conducted a retrospective cohort study in 161 children (106 with NOFTT and 55 health controls) at a single institution. Data on weight for age, height for age, body mass index, and biochemical parameters, indicating the children's nutritional and micronutrient status were reviewed via electronic medical records, and the two groups were compared.ResultsExcept inorganic phosphate levels, no statistically significant differences were seen in the laboratory findings indicating the children's nutritional and micronutrient status; notably, the inorganic phosphate levels were within the normal range in both groups. We then compared the severe NOFTT (weight for age below the first percentile) and control groups; however, no statistically significant differences were seen for any of the measured parameters.ConclusionMost children with NOFTT in this study had normal micronutrient levels and other laboratory findings. Therefore, element deficiencies should not be considered a natural consequence of NOFTT or in healthy children. Close monitoring and additional evaluations are needed.

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Section: Discussionmentioning

confidence: 99%

Micronutrients Are Not Deficient in Children with Nonorganic Failure to Thrive

Hong

Park

Kang

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

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“…In particular, these metals are cofactors for Cu, Zn-superoxide dismutase (SOD) and glutathione peroxidase (GPx) that play a signifi cant role in maintenance of redox homeostasis (Bettger, 1993). Zinc and selenium defi ciency is characterised by various clinical signs due to the participation of trace elements in numerous metabolic pathways (Lee, 2012). The incidence of poor zinc and selenium status is high in certain territories (Diplock, 1993;Prasad, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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Background.A signifi cant association between Zn and Se homeostasis exists. At the same time, data on the infl uence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the infl uence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats. Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the fi rst and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits. Results. Intragastric administration of zinc asparaginate signifi cantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats' organs. Moreover, a signifi cant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity. Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.

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“…Cu and Zn are two elements that are in competition with each other [ 35 ]. Cu/Zn ratio is considered an indicator of oxidative stress and inflammation assessment [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Selected Micronutrient Concentrations, Total Antioxidant Status, Pain Severity, and the Image of 1H MR Spectroscopy in Degenerative Spine Disease: A Case-Control Study

Jakoniuk

Biegaj

Kochanowicz

et al. 2022

JCM

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Osteoarthritis of the spine is a common disease and constitutes a significant problem in highly developed countries. Due to the aging of the population, the number of patients with advanced degenerative changes continues to grow. Trace elements and antioxidant status may play an active role in the pathogenesis of osteoarthritis of the spine. The aim of this study was to assess the relationship between total antioxidant status (TAS), the concentration of selected elements (Zn, Cu, Se, Mn) in the serum, nutritional and environmental factors, the severity of pain, and images of degenerative changes in the spine demonstrated in proton magnetic resonance spectroscopy (1H MRS). The study included 90 patients with degenerative spine disease and 40 healthy people. Serum Zn, Cu, Se, and Mn concentrations were determined by atomic absorption spectrometry. The Cu/Zn molar ratio was calculated. TAS was determined spectrophotometrically using a ready-made Randox kit. The severity of spine pain was assessed using the visual analogue scale VAS. In the 1H MRS study, the fat/water ratio was determined in L1 and L5 vertebral bodies and in the L4/5 intervertebral disc. In patients with osteoarthritis of the spine, there was a reduced concentration of Zn and Cu in the serum (0.77 ± 0.22 mg/L, 1.1 ± 0.35 mg/L) compared to the control group (0.83 ± 0.13 mg/L, 1.25 ± 0.41 mg/L, respectively). In the study group, we also observed a significantly lower Cu concentration in smokers (1.07 ± 0.35 mg/L) compared to non-smokers (1.17 ± 0.34 mg/L). A relationship between the female sex and a decreased concentration of TAS in the serum, both in people with degenerative spine disease and in healthy people, has been demonstrated. In patients with serum TAS levels below the reference values, the fat/water ratio was higher in the L5 spine shaft, while in those with elevated Mn levels, the value was higher in the L4/L5 intervertebral disc, which indicates a greater degree of degeneration in both cases. Patients with normal serum Cu concentration experienced lower pain intensity assessed in the VAS scale. The study showed some abnormalities in serum trace element levels and TAS in patients with osteoarthritis of the spine.

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Micronutrient Deficiency Syndrome: Zinc, Copper and Selenium

Cited by 5 publications

References 36 publications

Micronutrients Are Not Deficient in Children with Nonorganic Failure to Thrive

Micronutrients Are Not Deficient in Children with Nonorganic Failure to Thrive

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Relationship between Selected Micronutrient Concentrations, Total Antioxidant Status, Pain Severity, and the Image of 1H MR Spectroscopy in Degenerative Spine Disease: A Case-Control Study

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