Micronutrient deficiencies in children with coeliac disease; a double-edged sword of both untreated disease and treatment with gluten-free diet

McGrogan, Lorcan; Mackinder, Mary; Stefanowicz, Fiona; Aroutiounova, Maria; Catchpole, Andrew; Wadsworth, John; Buchanan, Evan G.; Cardigan, Tracey; Duncan, H. J.; Hansen, Richard; Russell, Richard K.; Edwards, Christine; Talwar, Dinesh; McGrogan, Paraic; Gerasimidis, Konstantinos

doi:10.1016/j.clnu.2021.03.006

Cited by 17 publications

(30 citation statements)

References 19 publications

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“…Celiac sprue has several nutritional deficits due to the localization of disease activity (namely, second portion of duodenum) such as vitamins and minerals, including zinc 75 . Indeed, decreased plasmatic zinc concentration has been described in both un‐treated and under gluten‐free diet patients 76 . In addition, microelement deficiency is significantly correlated with villous atrophy and its degrees 77…”

Section: Resultsmentioning

confidence: 99%

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Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

et al. 2022

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Microelements represent an emerging resource for medicine and its preventive branch. Zinc is the second most abundant element in our organism with peculiar physiologic functions and pathophysiologic implications in systemic and gastrointestinal (GI) diseases. It interacts very often with gut microbiota (GM) and can affect natural course of GI diseases through a bidirectional relationship with intestinal bugs. We aimed to review literature data regarding zinc chemistry, role in health, and GI diseases in man with a special focus on its interaction with GM. We conducted a search on the main medical databases for original articles, reviews, meta‐analyses, randomized clinical trials and case series using the following keywords and acronyms and their associations: zinc, microelements, gut microbiota, gut health, and COVID‐19. Zinc has a rapid and simple metabolism and limited storage within our body. Its efficacy on immune system modulation reflects on improved response to pathogens, reduced inflammatory response, and improved atopic/allergic reactions. Zinc is also involved in cell cycle regulation (namely, apoptosis) with potential anti‐cancerogenic effects. All these effects are in a “symbiotic” relationship with GM. Finally, zinc shows preliminary viral antireplicative effects. Zinc seems to gain more and more evidences on its efficacy in allergic, atopic and infectious diseases treatment, and prevention. COVID‐19 can be the booster for research on future applications of zinc as perfect “postbiotic” in medicine.

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Section: Resultsmentioning

confidence: 99%

“…75 Indeed, decreased plasmatic zinc concentration has been described in both un-treated and under glutenfree diet patients. 76 In addition, microelement deficiency is significantly correlated with villous atrophy and its degrees. 77 Therefore, zinc levels normalize after gluten-free diet.…”

Section: Zinc and Celiac Diseasementioning

confidence: 99%

Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

et al. 2022

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“…At the 12-month follow-up, vitamins E, K, B1 and ferritin had improved. 10 However, at the 12-month follow-up low levels of copper were noted in 15% of the patients.…”

Section: Nutritional Implicationsmentioning

confidence: 91%

“…24 Several studies have also reviewed growth, BMI and vitamin and mineral status in children and adolescents with CD. 10,25 In a longitudinal study of newly diagnosed children, serology to assess vitamin and mineral levels were collected at time of diagnosis and at 6 and 12 months on the GFD. 10 At diagnosis low nutrient levels were seen for ferritin, Vitamins E, B1, D, A, K, B6 and zinc.…”

Section: Nutritional Implicationsmentioning

confidence: 99%

“…10,25 In a longitudinal study of newly diagnosed children, serology to assess vitamin and mineral levels were collected at time of diagnosis and at 6 and 12 months on the GFD. 10 At diagnosis low nutrient levels were seen for ferritin, Vitamins E, B1, D, A, K, B6 and zinc. While several of the vitamin and mineral levels where low deficiency status was found only in Vitamins E (72%), B1 (21%) and D (20%).…”

Section: Nutritional Implicationsmentioning

confidence: 99%

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Review article: Dietary management of coeliac disease

Lee

2022

Aliment Pharmacol Ther

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To begin a discussion on the dietary management of coeliac disease (CD), a review of the multifaceted negative impact of the gluten-free diet (GFD) on the individual with CD needs to be described. The impact of diet and disease ranges from the cost of GF products, [1][2][3][4] to the limitations on an individuals' social life, [5][6][7] the impact on quality of life (QOL) and the nutritional concerns of the diet. [10][11][12] This chapter will explore the various issues confronting an individual with CD and discuss the importance of ongoing dietary management. | G FD IMPLEMENTATI ONThe only treatment for CD is the GFD. Once CD is confirmed the individual should receive in-depth dietary counselling. Dietary counselling should include an in-depth assessment of the nutritional, social, cultural, environmental factors that will impact the individual's ability to adopt and adhere to the GFD. Indeed, the process has shifted from one that focuses on just foods to avoid to one that evaluates the multiple factors in the client's life (social, cultural, environmental, biologic) that affect the individuals' food choices and dietary behaviour. 13 This is especially important when counselling an individual with CD on a GFD. Initially, the individual may just be focused on what to eliminate rather than assuring their new dietary pattern is diverse and well-rounded.

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Gluten‐free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease

Luque,

Crespo‐Escobar,

Hård af Segerstad

et al. 2024

J. pediatr. gastroenterol. nutr.

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Background and ObjectiveCoeliac disease is a chronic, immune‐mediated disorder for which the only treatment consists of lifelong strict adherence to gluten‐free diet (GFD). However, there is a lack of evidence‐based guidelines on the GFD dietary management of coeliac disease. This position paper, led by the Special Interest Group in coeliac disease of the European Society of Pediatric, Gastroenterology Hepatology, and Nutrition, supported by the Nutrition Committee and the Allied Health Professionals Committee, aims to present evidence‐based recommendations on the GFD as well as how to support dietary adherence.MethodsA wide literature search was performed using the MeSH Terms: “diet, gluten free,” “gluten‐free diet,” “diets, gluten‐free,” “gluten free diet,” and “coeliac disease” in Pubmed until November 8th, 2022.ResultsThe manuscript provides an overview of the definition of the GFD, regulations as basis to define the term “gluten‐free,” which foods are naturally gluten‐free and gluten‐containing. Moreover, it provides recommendations and educational tips and infographics on suitable food substitutes, the importance of reading food labels, risk of gluten cross‐contact at home and in public settings, nutritional considerations as well as factors associated to dietary adherence based on available evidence, or otherwise clinical expertise.ConclusionsThis position paper provides guidance and recommendations to support children with coeliac disease to safely adhere to a GFD.

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Micronutrient deficiencies in children with coeliac disease; a double-edged sword of both untreated disease and treatment with gluten-free diet

Cited by 17 publications

References 19 publications

Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

Review article: Dietary management of coeliac disease

Gluten‐free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease

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