Micronutrient Deficiencies Are Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms

Bledsoe, Adam C.; King, Katherine S.; Larson, Joseph J.; Snyder, Melissa R.; Absah, Imad; Choung, Rok Seon; Murray, Joseph A.

doi:10.1016/j.mayocp.2018.11.036

Cited by 43 publications

(41 citation statements)

References 23 publications

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“…One of the hypotheses which has been advanced to explain an association between CD and migraine sustains that there is a potential role of a generalized inflammatory response, rather than direct antibody-mediated mechanisms in the induction of migraine attacks via trigemino-vascular system activation [ 284 ]. Specifically, increased levels of pro-inflammatory cytokines such as IFN-γ and TFN-α might be involved in the modulation and release of CGRP from trigeminal endings, which are in turn implicated in neurogenic inflammation; thus, possibly explaining the appearance and progression of migraine in CD patients [ 285 , 286 ]. A similar mechanism has been advocated to explain the association between migraine and IBD.…”

Section: Headache and Immuno-mediated Gastrointestinal Disordersmentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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Several lines of evidence support a role of the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte subsets have been reported in headache patients. Secondly, several genetic and environmental pathogenic factors seem to be frequently shared by headache and immunological/autoimmune diseases. Accordingly, immunological alterations in primary headaches, in particular in migraine, have been suggested to predispose some patients to the development of immunological and autoimmune diseases. On the other hand, pathogenic mechanisms underlying autoimmune disorders, in some cases, seem to favour the onset of headache. Therefore, an association between headache and immunological/autoimmune disorders has been thoroughly investigated in the last years. The knowledge of this possible association may have relevant implications in the clinical practice when deciding diagnostic and therapeutic approaches. The present review summarizes findings to date regarding the plausible relationship between headache and immunological/autoimmune disorders, starting from a description of immunological alteration of primary headaches, and moving onward to the evidence supporting a potential link between headache and each specific autoimmune/immunological disease.

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Section: Headache and Immuno-mediated Gastrointestinal Disordersmentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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“…Upon diagnosis, nutritional deficiencies were found in vitamins and minerals; patients should be tested for micronutrient deficiencies, in particular iron, folic acid, vitamin B 12 , vitamin D, copper, and zinc. Celiac disease is a cause of anemia, usually due to the malabsorption of iron, folic acid, and vitamin B 12 [9]. Anemia is mainly due to the fact of iron deficiency as a consequence of iron malabsorption.…”

Section: Introductionmentioning

confidence: 99%

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

et al. 2019

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Celiac disease (CD) is a multisystemic disorder with different clinical expressions, from malabsorption with diarrhea, anemia, and nutritional compromise to extraintestinal manifestations. Anemia might be the only clinical expression of the disease, and iron deficiency anemia is considered one of the most frequent extraintestinal clinical manifestations of CD. Therefore, CD should be suspected in the presence of anemia without a known etiology. Assessment of tissue anti-transglutaminase and anti-endomysial antibodies are indicated in these cases and, if positive, digestive endoscopy and intestinal biopsy should be performed. Anemia in CD has a multifactorial pathogenesis and, although it is frequently a consequence of iron deficiency, it can be caused by deficiencies of folate or vitamin B 12 , or by blood loss or by its association with inflammatory bowel disease (IBD) or other associated diseases. The association between CD and IBD should be considered during anemia treatment in patients with IBD, because the similarity of symptoms could delay the diagnosis. Vitamin B 12 deficiency is common in CD and may be responsible for anemia and peripheral myeloneuropathy. Folate deficiency is a well-known cause of anemia in adults, but there is little information in children with CD; it is still unknown if anemia is a symptom of the most typical CD in adult patients either by predisposition due to the fact of age or because biochemical and clinical manifestations take longer to appear.

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“…Como se ha expuesto anteriormente, las deficiencias nutricionales son una consecuencia importante de la EC. Se ha demostrado que pacientes con EC, aun sin síntomas intestinales evidentes, presentan deficiencias significativas en los niveles de zinc, albúmina, cobre, vitamina B12 y folato, respecto a controles sanos [28]. La deficiencia de micronutrientes producto de la malabsorción que se presenta en pacientes de EC puede provocar la aparición de síndromes neurológicos.…”

Section: Manifestaciones Neurológicasunclassified

“…Dado el aumento de la prevalencia de pacientes con EC, sería adecuado una correcta valoración clínica con el fin de confirmar o descartar el padecimiento, ya que muchos de los afectados cursan asintomáticos para la enfermedad, pero desarrollan otras manifestaciones o patologías secundarias que se pueden evitar mediante un manejo integral de los hallazgos clínicos y de laboratorio, con el fin de evitar futuras complicaciones. Manifestaciones neurológicas [28,54]…”

Section: Conclusionesunclassified

Enfermedad celíaca y desarrollo de patologías secundarias

Sánchez

Yamasaki²

2020

Med. Lab.

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La enfermedad celíaca es una patología autoinmune sistémica caracterizada por un estado inflamatorio crónico de la mucosa y submucosa intestinal, de origen multifactorial y detonada por factores ambientales como la ingesta de gluten en individuos genéticamente predispuestos a sensibilizarse a dicha proteína. La prevalencia de la enfermedad a nivel mundial se estima entre 1,1% y 1,7%, según datos de seroprevalencia. Sin embargo, se considera que existe una importante cantidad de individuos no diagnosticados, quienes podrían llegar a desarrollar una serie de complicaciones debido a que no reciben el manejo adecuado. Por ello, el objetivo de esta revisión comprende valorar algunas de las patologías secundarias más frecuentes asociadas a la enfermedad celíaca, evidenciando la afectación sistémica que puede presentar un individuo con esta enfermedad.

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Micronutrient Deficiencies Are Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms

Cited by 43 publications

References 23 publications

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

Enfermedad celíaca y desarrollo de patologías secundarias

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