Micronuclei and sister chromatid exchanges induced by capsaicin in human lymphocytes

Marques, Sofia; Oliveira, Nuno G.; Chaveca, Teresa; Rueff, José

doi:10.1016/s1383-5718(02)00040-2

Cited by 30 publications

(31 citation statements)

References 24 publications

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“…Capsaicin induced the formation of micronuclei in a concentration-dependent manner in the CBMN assay; this increase was more evident in the absence of metabolic activation, with a maximum of 3.4-fold increase above the background. These results were interpreted by Marques et al (2002) to indicate that capsaicin is genotoxic. Chanda and colleagues (2004) found a positive result in the mouse lymphoma assay conducted with L5178Y tk þ /tk À mouse lymphoma cells, in the absence and presence of metabolic activation.…”

Section: In Vitro Genotoxicitymentioning

confidence: 98%

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

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Human exposure to capsaicin, the most abundant pungent chili pepper component, is ubiquitous. Evaluation of capsaicin's carcinogenic potential has produced variable results in in vitro and in vivo genotoxicity and carcinogenicity assays. The capsaicin tested in older studies was often from pepper plant extracts and included other capsaicinoids and diverse impurities. Recent studies utilizing high-purity capsaicin and standardized protocols provide evidence that the genotoxic and carcinogenic potential of capsaicin is quite low and that the purity of capsaicin is important. Several small epidemiological studies suggest a link between capsaicin consumption and stomach or gall bladder cancer, but contamination of capsaicin-containing foods with known carcinogens renders their interpretation problematic. The postulated ability of capsaicin metabolites to damage DNA and promote carcinogenesis remains unsupported. Anticancer activities of capsaicin have been widely reported, as it inhibits the activity of carcinogens and induces apoptosis in numerous cancer cell lines in vitro and explanted into rodents. Diverse mechanisms have been postulated for capsaicin's anticancer properties. One hypothesis is that inhibition of cytochrome P450 enzymes-particularly CYP2E1-retards carcinogen activation but is contradicted by the low potency of capsaicin for CYP inhibition. The potential for dietary capsaicin to act as a chemopreventative is now widely postulated.

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Section: In Vitro Genotoxicitymentioning

confidence: 98%

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

et al. 2012

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“…Capsaicin (Figure 1), a pungent constituent of pepper plants, has been widely recognized to have anti-cancer properties with inhibiting proliferation and inducing apoptosis in a large variety of human cancer cell lines [78], while its genotoxic and carcinogenic potential have been also reported in several articles [78][79][80]. Capsaicin is reported to inhibit TPA-induced NF-κB activation through suppressing IκB degradation and subsequent nuclear translocation of NF-κB/p65 [81].…”

Section: Cip1mentioning

confidence: 97%

Dietary Phytochemicals as Cancer Preventive Agents: Efficacy and Mechanisms

Sakai¹

2015

J Bioanal Biomed

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Despite significant advances in cancer therapeutic modalities, available anti-tumor drugs display limited efficacy and sometimes carry a risk of severe adverse side effect. Therefore, it is important to identify and develop cancer chemopreventive agents without toxicity. Epidemiological examinations in human populations and experimental rodent studies provide evidence that certain types of phytochemicals suppress development and growth of cancers at various organ sites. A number of clinical investigations have been also conducted and shown that dietary phytochemicals are able to inhibit tumorigenesis, indicating several phytochemicals are regarded as cancer chemopreventive agents. Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is considered as the most biologically active constituent in drinking tea with respect to inhibiting cell proliferation and inducing apoptosis in cancer cells. EGCG appears to directly target receptor tyrosine kinases with inhibiting activation of the receptors and down-stream signaling pathways. In addition, EGCG has improving effects against obesity and insulin resistance, which leads to suppressing the development of obesity-related malignancies. Other polyphenolic phytochemicals, including curcumin and resveratrol, are also reported to exert anti-cancer effect. In this review article, we summarize the potential of dietary phytochemicals as anti-cancer drugs and those possible mechanisms against cancer, especially chemopreventive effect of green tea catechins.

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“…Data from one micronucleus and sister chromatid exchange study in human lymphocytes were interpreted to show that capsaicin is genotoxic (Marques et al 2002). Capsaicin was also reported to induce DNA strand breaks in human neuroblastoma cells SHHY5Y (Richeux et al 1999).…”

Section: Genotoxicity Studies Of Capsaicin or Trans-capsaicinmentioning

confidence: 99%

“…The majority of the studies found in the literature (Marques et al 2002;Richeux et al 1999;Ames et al 1975;Fischer 1958) performed the Ames assay. There was one study each with the micronucleus assay, the sister chromatoid exchange assay and the assay investigating DNA strand breaks in human neuroblastoma cells Azizan and Blevins 1995;Nagabhuslan and Blide 1985;Marques et al 2002;Ames et al 1975).…”

Section: Chromosomal Aberration In Hpblsmentioning

confidence: 99%

“…There was one study each with the micronucleus assay, the sister chromatoid exchange assay and the assay investigating DNA strand breaks in human neuroblastoma cells Azizan and Blevins 1995;Nagabhuslan and Blide 1985;Marques et al 2002;Ames et al 1975). None of the studies was conducted using systematically pure capsaicin preparations, and it is very important to be able to attribute the results to capsaicin alone, not the impurities.…”

Section: Chromosomal Aberration In Hpblsmentioning

confidence: 99%

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Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings

et al. 2009

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(1) The capsaicin used in the physiological and pharmacological observations (in animals and human beings) chemically represents different chemical compounds, which can be obtained from the plants (paprika, chilli, etc.), (2) capsaicinoids are able to modify the capsaicin-sensitive afferent nerves, which have principle roles in the defence of different organs (including the gastrointestinal tract [against the different chemicals, heat, strech, chemical millieu-induced damage], (3) the application of capsaicin (capsaicinoids) can be repeated for the beneficial effects on the gastrointestinal tract as those in animal experiments. After this interdisciplinary and critical review, this paper demonstrates the well-planned research pathways of the discoveries of capsaicinoids from plant chemistry, via physiology, pharmacology and toxicology in animal experiments and human observations.

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Micronuclei and sister chromatid exchanges induced by capsaicin in human lymphocytes

Cited by 30 publications

References 24 publications

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

Dietary Phytochemicals as Cancer Preventive Agents: Efficacy and Mechanisms

Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings

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