Micronodular thymoma with lymphoid stroma: report of two cases and particular association with thymic lymphoid hyperplasia in one case

Mezni, Faouzi El; Braham, Emna; Ayadi, Aïda; Ismail, Olfa; Kilani, T.

doi:10.1080/00313020601027642

Cited by 13 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether further radiotherapy or chemotherapy is required for micronodular thymic carcinoma with lymphoid stroma warrants further investigation. The current study found that only 2 of the 18 patients reported recurrence or metastasis, and these patients were followed for 3 months to 22 years, indicating a lower degree of malignancy[2,24].…”

Section: Discussionmentioning

confidence: 90%

Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature

Wang¹,

Li²,

Song³

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUNDMicronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type of tumor is rare; therefore, the corresponding clinical guidelines, histopathological diagnostic criteria, prognostic factors, and therapeutic regimens have not been established.CASE SUMMARYThis study covers a novel presentation of MNC in a patient and summarizes the clinicopathological characteristics of this type of tumor by using pooled-analysis methods. Morphologically, this tumor type is a series of benign to malignant pedigrees. We establish the following criteria for the classification of micronodular thymic tumors with lymphoid stroma: (1) Tumor cells with moderate-to-severe dysplasia; (2) Tumor cell mitotic figures > 2/10 high-power fields; (3) Appearance of neoplastic necrosis; (4) No terminal deoxynucleotidyl transferase-positive immature T lymphocytes within the tumor; (5) Tumor cells with a Ki-67 index ≥ 10%; and (6) Tumor cells express CD5. Cases that fall into the borders of two categories in terms of morphology are attributed to atypical MNT. It is proposed that the diagnosis of MNT should be established on the diagnostic criteria mentioned above.CONCLUSIONOur diagnostic algorithm can effectively distinguish malignant tumors from benign tumors and provides a potent basis for predicting a prognosis, which offers a practical reference for oncologists and pathologists.

show abstract

Section: Discussionmentioning

confidence: 90%

Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature

Wang¹,

Li²,

Song³

et al. 2019

WJCC

View full text Add to dashboard Cite

show abstract

“…To date, only a few dozen cases of MNT have been described in the published literature ( Table 2 ). 3 – 6 , 8 , 9 , 10 , 12 – 19 Only three cases of MNTs have been reported to have an ectopic site and all of them were located in the neck. 4 – 6 In the current case, the eMNT was also found in the neck.…”

Section: Discussionmentioning

confidence: 99%

Ectopic micronodular thymoma with lymphoid stroma in the cervical region: a rare case associated with Langerhans cells proliferation

Meng²,

Xu³

et al. 2016

OTT

View full text Add to dashboard Cite

Micronodular thymoma (MNT) with lymphoid stroma is a rare thymic epithelial neoplasm with the characteristics of multiple nodules separated by abundant lymphoid stroma. MNTs mainly arise in the anterior mediastinum and thymus, while ectopic MNTs are extremely rarely seen. Here, we report an ectopic MNT that occurred in the neck of a 62-year-old woman. There were also scattered eosinophilic granulocytes and S100+/CD1a+ Langerhans cells within the tumor. This case provides a better understanding of such rare, poorly understood cases.

show abstract

“…4 Pseudo PelgereHu€ et anomaly, as a marker of granulocytic dysplasia, is only involved in neutrophils, which may occur in myelodysplastic syndrome (MDS) and acute and chronic leukaemias or can be drug-induced. 5,6 The Pelgere Hu€ et-like anomaly of lymphocytes is an extremely uncommon phenomenon that, to the best of our knowledge, has not been reported before. In contrast to the neutrophil Pelgere Hu€ et anomaly, which is caused by failure of nuclear segmentation, the lymphocyte PelgereHu€ et-like anomaly is caused by abnormal nuclear lobulation.…”

mentioning

confidence: 85%

“…A much smaller but more recent collection of data reported an incidence of 3.7%. 5 Rarely, MTLS may occur in association with thymic follicular hyperplasia 6 and other classical WHO subtypes of thymoma. 7 Also recognised is the span of differentiation from MTLS to its malignant counterpart, thymic carcinoma with lymphoid stroma, with the most important malignant criteria including the marked cytological atypia, mitotic rate and Ki-67 index, the presence of CD5þ tumour cells and a lack of TdTþ T cells within the tumour.…”

mentioning

confidence: 99%

Micronodular thymoma with lymphoid stroma: a clinicopathological study of five cases

et al. 2021

View full text Add to dashboard Cite

Micronodular thymoma with lymphoid stroma: report of two cases and particular association with thymic lymphoid hyperplasia in one case

Cited by 13 publications

References 5 publications

Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature

Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature

Ectopic micronodular thymoma with lymphoid stroma in the cervical region: a rare case associated with Langerhans cells proliferation

Micronodular thymoma with lymphoid stroma: a clinicopathological study of five cases

Contact Info

Product

Resources

About