Microneurosurgical treatment options in peripheral nerve compression syndromes after chemotherapy and radiation treatment

Chang, Eric I.; Rose, Michael I.; Rossi, Kristie; Elkwood, Andrew I.

doi:10.1002/jso.25254

Cited by 7 publications

(1 citation statement)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other chemotherapy consequences causing nerve injuries are capillary damage, 50 neuroinflammation, 54 swelling, and fibrosis, leading to compression of peripheral nerves. 55 Axonal damage in CIPN occurs through Wallerian degeneration but also apoptosis. Microtubule stabilization impairing its functions is implicated in inducing Wallerian degeneration, while apoptosis is connected with the destruction of mitochondria, DNA damage, neuroinflammation, and impaired cellular signaling.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy-Mediated Complications of Wound Healing: An Understudied Side Effect

Słonimska,

Sachadyn,

Zieliński

et al. 2024

Advances in Wound Care

View full text Add to dashboard Cite

Significance: Chemotherapy is a primary method to treat cancer. While chemotherapeutic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types. In the case of dermal cells and macrophages involved in wound healing, cytotoxicity often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent Advances: Despite its significant impact on patients' recovery from surgery, the issue of delayed wound healing in individuals undergoing chemotherapy remains inadequately explored. Critical Issues: This review aims to analyze the harmful impact of chemotherapy on wound healing. The analysis showed that chemotherapy drugs could inhibit cellular metabolism, cell division, and angiogenesis and lead to nerve damage. They impede the migration of cells into the wound and reduce the production of extracellular matrix. At the molecular level, they interfere with replication, transcription, translation, and cell signaling. This work reviews skin problems that patients may experience during and after chemotherapy and demonstrates insights into the cellular and molecular mechanisms of these pathologies. Future Directions: In the future, the problem of impaired wound healing in patients treated with chemotherapy may be addressed by cell therapies like autologous keratinocyte transplantation, which has already proved effective in this case. Epigenetic intervention to mitigate the side effects of chemotherapy is also worth considering, but epigenetic consequences of chemotherapy on skin cells are largely unknown and should be investigated.

show abstract

Section: Discussionmentioning

confidence: 99%