Microneedling with Dermaroller 192 needles along with 5-fluorouracil solution in the treatment of stable vitiligo

Kumar, Amit; Bharti, Rakesh; Agarwal, Shradha

doi:10.1016/j.jaad.2018.12.066

Cited by 18 publications

(22 citation statements)

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“…Tacrolimus and NB‐UVB are well‐established methods for treatment of vitiligo. Multiple studies revealed that the combination of tacrolimus with NB‐UVB hasten repigmentation compared with NB‐UVB alone . The efficacy of Mn with NB‐UVB was evaluated in a comparative study included 60 patients with acrofacial vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Ebrahim

Albalate

2020

J of Cosmetic Dermatology

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Background Combination therapies have reported to augment the repigmentation in vitiligo. Microneedling (Mn) facilitates drug delivery across the skin barrier. Objective To evaluate and compare the efficacy and safety of Mn combined with tacrolimus vs Mn alone or tacrolimus 0.1% ointment for treatment of localized and stable vitiligo. Patients and Method Ninety patients with vitiligo were randomized into three groups: group I received microneedling with tacrolimus, group II microneedling only both at 2 weeks interval for twelve sessions, and group III applied tacrolimus ointment 0.1% twice daily for 6 months. Skin biopsies were taken at baseline and after treatment. Results The overall improvement (76.6%) was significantly higher in the combined group compared with other groups. Repigmentation was excellent in 66.6 of group I vs 33.3% in the other two groups (P .03). A highly significant improvement of the extremities was observed in the combined group than in the other groups (P < .001). A fewer number of sessions have reported in the combined group (I) than in the microneedling group (II; P < .001). Immunohistochemical results showed a significantly higher expression of HMB‐45 in group I than in other two groups (P .04). Side effects were mild and tolerable in all groups. Conclusion The combination group has shown promising results over the other two groups.

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Section: Discussionmentioning

confidence: 99%

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Ebrahim

Albalate

2020

J of Cosmetic Dermatology

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“…15 The combination of microneedling with 5-FU yielded excellent results with good satisfaction rate in Kumar et al study. 20 Microneedling with triamcinolone acetonide solution yielded a fair-to-excellent satisfaction rate in 55% of patients whereas combining microneedling and triamcinolone acetonide solution with NB-UVB raised that percentage to 75%.…”

Section: Patient Satisfactionmentioning

confidence: 98%

“…11,[13][14][15][16][17][18] Visual analog scale was used in three studies. 10,[18][19][20] Other studies used investigator's global assessment (IGA) scoring and the measure of repigmentation diameter. 21,22…”

Section: Grading Scalementioning

confidence: 99%

“…Patients received 6 or 12 sessions of microneedling with 2 weeks intervals. 13,14,20 After microneedling, 5-FU solution (5%) was applied topically over affected areas and was covered under occlusive dressing for 1 day. 13,14 The patient was advised to apply 5-FU once daily for 2 weeks.…”

Section: Microneedling In Combination With 5-fu Biotherapymentioning

confidence: 99%

“…13 Similar case reports showed complete repigmentation in acral, face, and back areas treated with 5-FU and microneedling. 19,20 3.1.7 | Microneedling with NB-UVB and PDT, or with triamcinolone acetonide (applied under coverage for 2 hours) and were exposed to PDT with red light (630 nm) for 8 minutes (37 J/cm 2 ). 10 This study failed to prove any additional efficacy of PDT to microneedling therapy and 40% of patients had a clinical response vs 60% in the other group (microneedling + NB-UVB).…”

Section: Microneedling In Combination With 5-fu Biotherapymentioning

confidence: 99%

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Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

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Microneedling was initially introduced for skin rejuvenation; however, this minimally invasive procedure is now being used for the treatment of multiple dermatological conditions. Recent reports have shown its efficacy in the treatment of vitiligo. This review analyzes the current literature on microneedling techniques, efficacy, and safety for vitiligo treatment. An extensive PubMed was done to identify the literature on microneedling treatment for vitiligo. Case reports, case series, and clinical trials were included in this review. All 14 articles evaluated showed improvement of vitiligo lesions after microneedling treatment. The combination of microneedling and topical tacrolimus, 5-fluorouracil, topical calcipotriol and betamethasone, narrowband ultraviolet B with or without photodynamic therapy, and triamcinolone acetonide solution yielded more efficacy than microneedling monotherapy. Microneedling is a safe and efficient technique in the treatment of vitiligo. Thus, it can be an alternative treatment for vitiligo especially when the latter is resistant to conventional therapies.

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Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Ertas,

Erdem

et al. 2024

Small

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Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture the stratum corneum layer of the skin and have lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, and drug administration. MNs offer limited invasiveness, ease of application, and minimal discomfort. Initially manufactured solely from metals, MNs are now available in polymer‐based varieties. MNs can be used to create systems that deliver drugs and chemicals uniformly, collect bodily fluids, and are stimulus‐sensitive. Although these advancements are favorable in terms of biocompatibility and production costs, they are insufficient for the therapeutic use of MNs. This is the first comprehensive review that discusses individual MN functions toward the evolution and development of smart and multifunctional MNs for a variety of novel and impactful future applications. The study examines fabrication techniques, application purposes, and experimental details of MN constructs that perform multiple functions concurrently, including sensing, drug‐molecule release, sampling, and remote communication capabilities. It is highly likely that in the near future, MN‐based smart devices will be a useful and important component of standard medical practice for different applications.

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Microneedling with Dermaroller 192 needles along with 5-fluorouracil solution in the treatment of stable vitiligo

Cited by 18 publications

References 1 publication

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment

Microneedling in vitiligo: A systematic review

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

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