Microneedles in Smart Drug Delivery

Bilal, Muhammad; Mehmood, Shahid; Raza, Ali; Hayat, Uzma; Rasheed, Tahir; Iqbal, Hafiz M.N.

doi:10.1089/wound.2019.1122

Cited by 25 publications

(25 citation statements)

References 121 publications

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“…Recent studies have investigated the potential of M/NA skin patches for different biomedical/pharmaceutical applications, such as vaccinations, gene therapy, cancer therapy, and obesity treatment. [ 201 ] The potential of M/NA for the delivery of bioactive molecules, proteins, antibodies, antigens, and other biotechnological active ingredients has been shown in previous literature. [ 202,203 ] Chi et al.…”

Section: Microneedle/nanoneedle Skin Patches For Drug Delivery Applications In Wound Healingmentioning

confidence: 99%

“…The obtained results from this study revealed the robust potential of this bandage concept to be implemented in daily life and provide an attractive solution for remote monitoring of the wound conditions and consequently reduces the prospect burden on patients and health care services. [ 201 ]…”

Section: D Printing Technologies For the Development Of Wound Dressingsmentioning

confidence: 99%

“…The 3D‐printed wound dressings have demonstrated a huge potential for facilitating skin defects in the last few years. [ 201,73 ] Full‐thickness burns are among the skin defects that are difficult to heal, especially for the sensitive parts of the body such as the head and neck. Visscher et al.…”

Section: D Printing Technologies For the Development Of Wound Dressingsmentioning

confidence: 99%

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Wound Healing: From Passive to Smart Dressings

Farahani

Shafiee

2021

Adv Healthcare Materials

374

219

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The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on the patients and healthcare systems. Although, the application of traditional wound dressings contributes to an effective wound healing outcome, yet, the complexity of the healing process remains a major health challenge. Recent advances in materials and fabrication technologies have led to the fabrication of dressings that provide proper conditions for effective wound healing. The 3D‐printed wound dressings, biomolecule‐loaded dressings, as well as smart and flexible bandages are among the recent alternatives that have been developed to accelerate wound healing. Additionally, the new generation of wound dressings contains a variety of microelectronic sensors for real‐time monitoring of the wound environment and is able to apply required actions to support the healing progress. Moreover, advances in manufacturing flexible microelectronic sensors enable the development of the next generation of wound dressing substrates, known as electronic skin, for real‐time monitoring of the whole physiochemical markers in the wound environment in a single platform. The current study reviews the importance of smart wound dressings as an emerging strategy for wound care management and highlights different types of smart dressings for promoting the wound healing process.

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Section: Microneedle/nanoneedle Skin Patches For Drug Delivery Applications In Wound Healingmentioning

confidence: 99%

Section: D Printing Technologies For the Development Of Wound Dressingsmentioning

confidence: 99%

Section: D Printing Technologies For the Development Of Wound Dressingsmentioning

confidence: 99%

See 1 more Smart Citation

Wound Healing: From Passive to Smart Dressings

Farahani

Shafiee

2021

Adv Healthcare Materials

374

219

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“…Although smart device‐based therapy is a relatively premature concept in intraoral drug delivery, several types of devices are in the premarket research stage, including microneedles (MNs), microcontainers (MCs), braces delivery devices, and so on 112–115 . As a promising diagnostic and therapeutic tool in the medical field, MNs have been confirmed to provide satisfactory painless, minimally invasive, and continuous intraoral drug delivery, significantly promoting patient compliance, minimizing needle phobia, and elevating bioavailability 116–118 . Caffarel‐Salvador et al 119 .…”

Section: Smart Intraoral Drug Delivery Systemsmentioning

confidence: 99%

Smart intraoral systems for advanced drug delivery

Liu

Guo

et al. 2022

MedComm – Biomaterials and Applications

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Drug administration through the oral cavity is considered to be a convenient, effective, and time-saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties.Without the degradation in gastrointestinal tract and first-pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproduc-MedComm -Biomaterials and Applications.

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“…A variety of needle shapes and sizes are being created as a result of the very flexible nature of the material, as very small or micron-sized structures are necessary for MN formulation. [72] Crystalline silicon with elastic moduli values ranging from 50 to 180 GPa and mechanical strength comparable to that of muscle silicon with muscular mechanical strength. On the basis of the reactive ion etching approach, short silicon MNs created using a dry etching process with a chromium mask.…”

Section: Siliconmentioning

confidence: 99%

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Patel¹,

Parikh²,

Patel³

et al. 2021

TJOPAM

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Because of the limitations of the oral drug delivery system, as well as the discomfort associated with the usage of needles in the case of injections, drug delivery research has shifted significantly toward the transdermal route of administration. Topical creams, gels, and transdermal patches are the most often utilised means of transdermal administration of drugs. Since the stratum corneum layer of the skin acts as a barrier to a drug molecule, the effect of the majority of therapeutic agents is limited. As a result, only a small number of molecules are able to reach the site of action. A new type of delivery method, known as microneedles, is being developed to improve the distribution of drugs through this route while also overcoming the various issues associated with existing formulations. Non-invasive and painless feature of microneedles have making them ideal for self-administration. This review describes various type of microneedles and their design, fabrication methodology, various materials used in fabrication of microneedles, drug release mechanism from the microneedles, evaluation parameters, it’s biological application, update about recent clinical studies and in last, challenges and future perspective of microneedles as drug delivery system.

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Microneedles in Smart Drug Delivery

Cited by 25 publications

References 121 publications

Wound Healing: From Passive to Smart Dressings

Wound Healing: From Passive to Smart Dressings

Smart intraoral systems for advanced drug delivery

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

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