Microneedles in Improving Skin Appearance and Enhanced Delivery of Cosmeceuticals

Recent Advances in Microneedling-Assisted Cosmetic Applications

“…In cosmetics and transdermal applications, where the skin is pretreated with the Dermaroller, followed by the use of the transdermal formulation [28] Primarily in cosmetics [13] Uniform pressure on the skin Depending on the user, no way to control how much pressure is on the skin, except for automated Dermarollers [28] Uniform pressure [28] Advantages Easy-to-use, home-usable Dermaroller, applied across the skin vertically, horizontally, and diagonally [43,44] An inexpensive office maneuver, risk-free procedure as the needles are hidden in a guide, less painful, used to treat facial wrinkles due to aging and smoking, penetrates the skin at a perpendicular angle, is suitable for delicate and specific areas, and does not require pressure on the skin as in the case of Dermaroller [43,45,46] Disadvantages Controlling the pressure has to come with practice and experience (except for automated devices); difficult to treat small areas or localized scars [43] The disadvantages of Dermaroller are overcome by Dermapen [44] Side effects Bleeding, swelling, bruising, redness, temporary erythema, pain, burning sensation, edema, itching, and peeling (these typically go after a few days or weeks), along with a risk of tips breaking in the skin [27,39] Redness and swelling that disappears within 2-3 days [43] Microneedling setup Accessible for home use at low cost or by skin professionals in clinics [25,47,48] Recovery of the skin barrier function…”

“…Several hours to 72 h of device usage, based on age, skin elasticity, skin application site, needle length, number of applications, and application pressure [44,49] Recently, a miniature version of Dermaroller ® (Dermastamp ® , Figure 2) has been fabricated to reach the small, confined areas that are difficult to reach with Dermaroller ® [13,40,50,51]. The Dermastamp ® (Teoxy Beauty, Wuhan, China) is a non-oscillating device composed of microneedle arrays with 42 needles per stamp of 1000 µm in length, 0.12 mm in diameter, a 21-25 µm tip radius, and curved conical geometry, arranged at the base of the stamp [52].…”