Microneedles for transdermal diagnostics: Recent advances and new horizons

Liu, Gui-Shi; Kong, Ying; Wang, Yensheng; Luo, Yunhan; Fan, Xudong; Xie, Xi; Yang, Bo‐Ru; Wu, Minxian

doi:10.1016/j.biomaterials.2019.119740

Cited by 162 publications

(150 citation statements)

References 164 publications

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“…The SHPM-OS sensor in this study maintained stable sensitivity within 20 days, which could relieve the pain of people with diabetes caused by finger-sticking. Moreover, a typical amperometric glucose sensor has to experience complicated immobilization procedure and degradation of enzyme, oxygen limitation and fibrosis [5,50]. Improving the loading enzyme capacity of the electrode [51][52][53][54], optimizing the immobilization methods [55] and enhancing enzyme activity [32,46] of GOD can slow down the degradation rate of the enzyme.…”

Section: Discussionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes.

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Section: Discussionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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“…Various types of MNs including hollow MNs, solid MNs, and swellable MNs have been reported to be used in ISF extraction. Hollow MNs rely on capillary action for collection of ISF, while swellable MNs depend on fluid diffusion and material absorption [28]. Because of its polymeric crosslinking network structure and hydrophilic groups, it can swell and absorb ISF.…”

Section: Biofluids Extractionmentioning

confidence: 99%

“…Many reviews on microneedle technology have been published in recent years. However, many of them typically focus on a specific aspect, such as materials science and manufacture [26], glucose monitoring [27], polymeric MNs' application [14], diagnostics [28,29], and drug delivery [30,31]. The systematical review, which elaborates on the basic knowledge and main points of MNs, and covers the latest application of diagnosis and therapy, is still in its infancy [32].…”

Section: Introductionmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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“…Morphologically, MNs are categorised into five types, namely, hollow, solid, coated, dissolving, and swellable MNs [31]. As discussed in numerous reviews [3,4,32] on the topic, the MN types must be properly chosen according to their applications. Hollow MNs perform in the same way as regular hypodermic needles but have much shorter capillaries within them.…”

Section: Morphological Variation Of Mnsmentioning

confidence: 99%

Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

et al. 2020

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In the last two decades, microneedles (MNs) have received significant interest due to their potential for painless transdermal drug delivery (TDD) and minimal skin damage. MNs have found applications in a range of research and development areas in drug delivery. They have been prepared using a variety of materials and fabrication techniques resulting in MN arrays with different dimensions, shapes, and geometries for delivery of a variety of drug molecules. These parameters play crucial roles in determining the drug release profiles from the MNs. Developing mathematical modelling, simulation, and optimisation techniques is vital to achieving the desired MN performances. These will then be helpful for pharmaceutical and biotechnological industries as well as professionals working in the field of regulatory affairs focusing on MN based TDD systems. This is because modelling has a great potential to reduce the financial and time cost of both the MNs’ studies and manufacturing. For example, a number of robust mathematical models for predicting the performance of the MNs in vivo have emerged recently which incorporate the roles of the structural and mechanical properties of the skin. In addressing these points, this review paper aims to highlight the current status of the MN modelling research, in particular, the modelling, simulation and optimisation of the systems for drug delivery. The theoretical basis for the simulation of MN enhanced diffusion is discussed within this paper. Thus, this review paper provides a better understanding of the modelling of the MN mediated drug delivery process.

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Microneedles for transdermal diagnostics: Recent advances and new horizons

Cited by 162 publications

References 164 publications

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Engineering Microneedles for Therapy and Diagnosis: A Survey

Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

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