Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies

Kang, Nae‐Won; Kim, Sungho; Lee, Jae-Young; Kim, Ki-Taek; Choi, Yeon Joo; Oh, Yujeong; Kim, Jongchan; Kim, Dae‐Duk; Park, Jung Hwan

doi:10.1080/17425247.2021.1828860

Cited by 46 publications

(24 citation statements)

References 179 publications

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“…A proper program framework may be appropriate [ 381 , 382 , 383 ]; Repetitive use of immunological effects: repeated insertion of MN into the skin may cause immune reactions. The regulators should be assured of immunological protection [ 139 , 384 , 385 ]; Profile for long-term security: to date, human volunteers have conducted short-term security experiments. The long-term protection of the MN program should therefore be taken into consideration from the point of view of sporadic and repetitive demands [ 379 , 386 , 387 ].…”

Section: Regulatory Issues With Polymeric Microneedlesmentioning

confidence: 99%

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Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Section: Regulatory Issues With Polymeric Microneedlesmentioning

confidence: 99%

“…Repetitive use of immunological effects: repeated insertion of MN into the skin may cause immune reactions. The regulators should be assured of immunological protection [ 139 , 384 , 385 ];…”

Section: Regulatory Issues With Polymeric Microneedlesmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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“…With different geometries and designs [3,4], such as solid, hollow, coated, or biodegradable [5] needle types in the scale of micrometers and nanometers [6], microneedle arrays (MNAs) can be fabricated with numerous methods such as 3D printing [7,8]. MNAs can be inserted into a target area, even within the depth of skin epidermis and thus they have emerging biomedical applications in drug delivery systems [9][10][11][12] with the capability of programmed deliveries of drug doses for multiple-injection therapies such as vaccination [13], sampling interstitial fluid (ISF) [14,15] biomarker detection [16], enhanced wound healing [17], fertility control [18], point-of-care (POC) setups and diagnostic tests [19,20], DNA extraction [21,22], cancer therapy [23], and force sensing [24].…”

Section: Introductionmentioning

confidence: 99%

Finger-Actuated Microneedle Array for Sampling Body Fluids

2021

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The application of microneedles (MNs) for minimally invasive biological fluid sampling is rapidly emerging, offering a user-friendly approach with decreased insertion pain and less harm to the tissues compared to conventional needles. Here, a finger-powered microneedle array (MNA) integrated with a microfluidic chip was conceptualized to extract body fluid samples. Actuated by finger pressure, the microfluidic device enables an efficient approach for the user to collect their own body fluids in a simple and fast manner without the requirement for a healthcare worker. The processes for extracting human blood and interstitial fluid (ISF) from the body and the flow across the device, estimating the amount of the extracted fluid, were simulated. The design in this work can be utilized for the minimally invasive personalized medical equipment offering a simple usage procedure.

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“…Unfortunately, these methods have shown significant economic limitations [18]. Therefore, microneedles are the most widely studied method to administer micro and macromolecules through the skin [19]. However, many researchers do not consider this delivery method as a "needle-free" approach.…”

Section: Introductionmentioning

confidence: 99%

The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination

et al. 2021

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The World Health Organization estimates that the pandemic caused by the SARS-CoV-2 virus claimed more than 3 million lives in 2020 alone. This situation has highlighted the importance of vaccination programs and the urgency of working on new technologies that allow an efficient, safe, and effective immunization. From this perspective, nanomedicine has provided novel tools for the design of the new generation of vaccines. Among the challenges of the new vaccine generations is the search for alternative routes of antigen delivery due to costs, risks, need for trained personnel, and low acceptance in the population associated with the parenteral route. Along these lines, transdermal immunization has been raised as a promising alternative for antigen delivery and vaccination based on a large absorption surface and an abundance of immune system cells. These features contribute to a high barrier capacity and high immunological efficiency for transdermal immunization. However, the stratum corneum barrier constitutes a significant challenge for generating new pharmaceutical forms for transdermal antigen delivery. This review addresses the biological bases for transdermal immunomodulation and the technological advances in the field of nanomedicine, from the passage of antigens facilitated by devices to cross the stratum corneum, to the design of nanosystems, with an emphasis on the importance of design and composition towards the new generation of needle-free nanometric transdermal systems.

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Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies

Cited by 46 publications

References 179 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Finger-Actuated Microneedle Array for Sampling Body Fluids

The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination

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