Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review

Gowda, B.H. Jaswanth; Ahmed, Mohammed Gulzar; Hani, Umme; Kesharwani, Prashant; Wahab, Shadma; Paul, Karthika

doi:10.1016/j.ijpharm.2023.122591

Cited by 23 publications

(15 citation statements)

References 129 publications

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“…[187,188] Despite these advantages, it is challenging to load high concentrations of lipophilic drugs into MNs. [189] In this regard, incorporating solubility-enhanced anticancer drugs via NSs into dissolving, coated, and hydrogel-forming MNs could overcome one of the most significant drawbacks of MNs, i.e., low drug loading capacity. Furthermore, the NSs-loaded MN patch could be utilized to treat cutaneous skin cancer and breast cancer.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Gowda,

Ahmed,

Almoyad

et al. 2023

Adv Funct Materials

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Nanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They are categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, and bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids and mesh‐like network that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, or complexion. The voids can be further sealed using suitable lipids or polymers to avoid leakage of drugs at the non‐target site, protect therapeutics from biological conditions, and control the release of therapeutics for a prolonged period. Recently, nanosponges have grasped the attention of researchers in the area of cancer by overcoming the drawbacks associated with the conventional delivery of immunotherapeutic, targeted therapeutic, and chemotherapeutic agents. Interestingly, several reports have also witnessed their potential in cancer theranostics. Owing to this supremacy, nanosponges could be an apt platform for cancer therapy and diagnosis. The current review discusses the general aspects, types, and preparation methods of nanosponges. In addition, the ambit of nanosponges in treating different types of cancer is meticulously discussed, along with detailed descriptions of their corresponding patents. Furthermore, the role of nanosponges in phototherapy and cancer theranostics are selectively canvassed.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%

Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Gowda,

Ahmed,

Almoyad

et al. 2023

Adv Funct Materials

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“…10,11 Because of their painless, minimally invasive, and user-friendly feature, several MAPs have been developed for the transdermal delivery of MTX for psoriasis treatment. 12 For example, Du et al developed a dissolvable microneedle array patch (MAP) loaded with methotrexate (MTX) based on hyaluronic acid (HA). 13 These patches have proven to be more effective than orally taking the same dose of the drug in mitigating psoriatic symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Microneedles (MNs) or microneedle array patches (MAPs) have emerged as the primary method for transdermal drug delivery, garnering substantial global interest in recent times . These tiny projections can penetrate the skin’s stratum corneum barrier, allowing for precise drug delivery to the viable epidermis and dermal layers while avoiding stimulation of blood vessels or nerve endings. , Because of their painless, minimally invasive, and user-friendly feature, several MAPs have been developed for the transdermal delivery of MTX for psoriasis treatment . For example, Du et al developed a dissolvable microneedle array patch (MAP) loaded with methotrexate (MTX) based on hyaluronic acid (HA) .…”

Section: Introductionmentioning

confidence: 99%

Efficient Loading and Sustained Delivery of Methotrexate Using a Tip-Swellable Microneedle Array Patch for Psoriasis Treatment

Zhao,

Li,

Ling

et al. 2024

ACS Biomater. Sci. Eng.

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Methotrexate (MTX), a primary treatment for moderate to severe psoriasis, is limited in clinical use due to suboptimal results and severe side effects from subcutaneous (SC) injection and oral administration. Microneedles offer a promising alternative for direct MTX delivery to targeted skin lesions, but issues such as drug wastage, dosage inaccuracy, and limited drug residence time in the lesions remain. This study introduces a tipswellable microneedle array patch (TSMAP) using photo-crosslinked methacrylated hyaluronic acid (MeHA) and biocompatible resin for effective MTX loading and sustained delivery. A two-cast micromolding with vacuum drying is employed to concentrate cross-linked MeHA in about 30% of the needle's height at the tip, thereby ensuring that only the TSMAP tip swells. Efficient MTX loading into TSMAP tips is achieved through a 30 s drug solution immersion and 10 min drying, potentially minimizing drug waste from incomplete skin insertion due to skin elasticity. The MTX-loaded TSMAP effectively penetrates both porcine and psoriasis-like mouse skin with its tips detaching from the resin substrate and embedding deeply into the skin tissue, thereby functioning as a drug release reservoir. TSMAP significantly prolongs drug retention in skin compared with SC injection and dissolvable microneedles. The in vivo study demonstrates that TSMAP-mediated MTX delivery substantially enhances therapeutic outcomes in alleviating psoriasis symptoms and downregulating psoriasis-associated cytokines, outperforming oral administration, SC injection, and dissolvable microneedles. Thus, TSMAP could offer an efficient and user-friendly alternative for drug administration in the treatment of various skin diseases.

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“…MN devices consist of micron‐sized needles arranged in a collection on a patch with appropriate mechanical strength, toughness, and length to break through the SC for drug delivery while ensuring painlessness and minimal invasiveness due to their small size, resulting in good patient compliance and improved efficacy. [ 4 ] With the breakthrough of smart biomaterials, MNs have the functions of biosignal sensing, [ 5 ] drug dosage control, [ 6 ] drug response release, [ 7 ] vaccine delivery, [ 8 ] diagnostics, [ 9 ] etc., which bring more possibilities for biomedical and other research fields. And the MN array encapsulated with responsive nanoparticles (NPs) combines the MN and NP strategies with the advantages of good drug stability, high bioavailability, and good targeting, which has received more and more attention as a multifunctional platform in TDD systems.…”

Section: Introductionmentioning

confidence: 99%

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

Xie,

Li,

Shi

et al. 2024

Advanced NanoBiomed Research

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Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneedle transdermal drug delivery eliminates the need to pass through the gastrointestinal tract and liver, reducing the metabolic consumption of drugs by first‐pass effect. While compared with intravenous drug delivery, microneedle transdermal drug delivery reduces patient discomfort and does not require professional administration. However, there are few review articles on microneedles loaded with responsive nanoparticles. Herein, the current researches on microneedles loaded with specific responsive nanoparticles such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, and multiresponsive, and the biomedical application of these microneedle array systems are summarized. In addition, the challenges and prospects of microneedle strategies loaded with responsive nanoparticles are briefly discussed, which will facilitate the development of such versatile drug‐delivery strategy.

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Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review

Cited by 23 publications

References 129 publications

Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Efficient Loading and Sustained Delivery of Methotrexate Using a Tip-Swellable Microneedle Array Patch for Psoriasis Treatment

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

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