Microneedle technology for immunisation: Perception, acceptability and suitability for paediatric use

Marshall, Sarah; Sahm, Laura J.; Moore, Anne

doi:10.1016/j.vaccine.2015.12.002

Cited by 40 publications

(23 citation statements)

References 48 publications

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“…This is consistent with previous studies reporting less pain from microneedle administration compared to injection [17, 19, 20] and reporting overall preference of microneedle patches over drug or vaccine delivery by injection [19, 21-23]. …”

Section: Discussionsupporting

confidence: 92%

Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects

et al. 2017

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To support translation of microneedle patches from pre-clinical development into clinical trials, this study examined the effect of microneedle patch application on local skin reactions, reliability of use and acceptability to patients. Placebo patches containing dissolving microneedles were administered to fifteen human participants. Microneedle patches were well tolerated in the skin with no pain or swelling and only mild erythema localized to the site of patch administration that resolved fully within seven days. Microneedle patches could be administered by hand without the need of an applicator and delivery efficiencies were similar for investigator-administration and self-administration. Microneedle patch administration was not considered painful and the large majority of subjects were somewhat or fully confident that they self-administered patches correctly. Microneedle patches were overwhelmingly preferred over conventional needle and syringe injection. Altogether, these results demonstrate that dissolving microneedle patches were well tolerated, easily usable and strongly accepted by human subjects, which will facilitate further clinical translation of this technology.

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Section: Discussionsupporting

confidence: 92%

Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects

et al. 2017

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“…37,114,115 In most of these studies, commercially available hollow-microneedle systems were used while the clinical studies of polymeric microneedles are limited. [116][117][118][119][120] Two phase I studies have investigated the piercing ability and safety of HA-based dissolving microneedles. The results showed that with the assistance of an applicator, the microneedles can be reproducibly penetrated into the skin with no obvious side effect.…”

Section: Discussionmentioning

confidence: 99%

Current Advances in Sustained Release Microneedles

Sun

2020

Pharmaceutical Fronts

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AbstractMicroneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payloads, limiting therapeutic utility of the biotherapeutics. Recently, several types of microneedles with sustained release properties, including slow-dissolving microneedles made of hydrophilic polymers, degradable microneedles made of hydrophobic polymers, and bioresponsive microneedles made of bioresponsive polymers, have been developed and investigated for intradermal delivery of the biotherapeutics, aiming for improving their therapeutic potency, reducing side effects and administration frequency, and further improving patient compliance. In this review, we introduced different types of microneedles that have been designed for sustained release of the payloads, summarized various applications of these microneedles, and discussed the future prospects of this technology.

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“…This enhanced immune response is believed to be due to resident antigen‐presenting cells, such as Langerhans and dermal dendritic cells found in the skin . In addition, MN patches can be administered by minimally trained personnel including patients, enable increased vaccine thermostability, generate no sharps waste if designed using water‐soluble materials that dissolve in the skin, and have a low expected cost of manufacturing, all of which facilitate vaccination in developing countries and in mass vaccination campaigns during outbreaks . To date, MN‐based delivery systems have also been studied for delivery of a variety of vaccines against a range of different diseases …”

mentioning

confidence: 99%

Ebola Vaccination Using a DNA Vaccine Coated on PLGA‐PLL/γPGA Nanoparticles Administered Using a Microneedle Patch

Yang

Guo

et al. 2016

Adv Healthcare Materials

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Microneedle technology for immunisation: Perception, acceptability and suitability for paediatric use

Cited by 40 publications

References 48 publications

Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects

Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects

Current Advances in Sustained Release Microneedles

Ebola Vaccination Using a DNA Vaccine Coated on PLGA‐PLL/γPGA Nanoparticles Administered Using a Microneedle Patch

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