Microneedle patch drug delivery in the gut

Prausnitz, Mark R.; Gomaa, Yasmine; Li, Wei

doi:10.1038/s41591-019-0606-0

Cited by 45 publications

(29 citation statements)

References 9 publications

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“…[ 34 ] Ever since, the field of microneedle‐based transdermal drug delivery has experienced a rapid expansion for administering a wide variety of drugs, vaccines, or even genes. [ 35–43 ] Several of these microneedle delivery devices have been FDA‐approved or are currently in the clinical evaluation stage.…”

Section: Historical Evolution Of Microneedle‐based Sensorsmentioning

confidence: 99%

Lab under the Skin: Microneedle Based Wearable Devices

Teymourian

Tehrani

Mahato

et al. 2021

Adv Healthcare Materials

184

140

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While the current smartwatches and cellphones can readily track mobility and vital signs, a new generation of wearable devices is rapidly developing to enable users to monitor their health parameters at the molecular level. Within this emerging class of wearables, microneedle‐based transdermal sensors are in a prime position to play a key role in synergizing the significant advantages of dermal interstitial fluid (ISF) as a rich source of clinical indicators and painless skin pricking to allow the collection of real‐time diagnostic information. While initial efforts of microneedle sensing focused on ISF extraction coupled with either on‐chip analysis or off‐chip instrumentation, the latest trend has been oriented toward assembling electrochemical biosensors on the tip of microneedles to allow direct continuous chemical measurements. In this context, significant advances have recently been made in exploiting microneedle‐based devices for real‐time monitoring of various metabolites, electrolytes, and therapeutics and toward the simultaneous multiplexed detection of key chemical markers; yet, there are several grand challenges that still exist. In this review, we outline current progress, recent trends, and new capabilities of microneedle‐empowered sensors, along with the current unmet challenges and a future roadmap toward transforming the latest innovations in the field to commercial products.

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Section: Historical Evolution Of Microneedle‐based Sensorsmentioning

confidence: 99%

Lab under the Skin: Microneedle Based Wearable Devices

Teymourian

Tehrani

Mahato

et al. 2021

Adv Healthcare Materials

184

140

View full text Add to dashboard Cite

show abstract

“…Then the arms press the microneedle patches against the intestinal wall to penetrate the epithelia barriers. A company (Rani Therapeutics, San Jose, CA, USA) is developing a related technology to deliver oral biologics, which has been studied in clinical trials 287 . However, future studies have to be determined whether the microneedle cause distension of small intestine.…”

Section: Current Strategies Towards Enhancement Of the Oral Absorption Of Ppsmentioning

confidence: 99%

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Zhu

Chen

Paul

et al. 2021

Acta Pharmaceutica Sinica B

158

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Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route. Given the big demand for oral administration in clinical use, a variety of researches focused on developing new technologies to overcome GI barriers of PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, as well as intestinal microdevices. Some new technologies have been developed under clinical trials and even on the market. This review summarizes the history, the physiological barriers and the overcoming approaches, current clinical and preclinical technologies, and future prospects of oral delivery of PPs.

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“…The incorporation of microneedles into pills that push into the GI lining (intra-enteral injection) to bypass these challenges can improve the bioavailability of a biologically active macromolecule [199]. An illustration of the working mechanism of such microneedle pills is represented in Fig.…”

Section: Esophageal and Stomach Deliverymentioning

confidence: 99%

“…Delivery of biologics via the GI tract using a luminal unfolding microneedle injector (LUMI). Reprinted by permission from [199]. Nature, Copyright (2019).…”

Section: Esophageal and Stomach Deliverymentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

152

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Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

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Microneedle patch drug delivery in the gut

Cited by 45 publications

References 9 publications

Lab under the Skin: Microneedle Based Wearable Devices

Lab under the Skin: Microneedle Based Wearable Devices

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Micro and nanoscale technologies in oral drug delivery

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