Microneedle Array: Applications, Recent Advances, and Clinical Pertinence in Transdermal Drug Delivery

Halder, Jitu; Gupta, Sudhanshu; Kumari, Rakhi; Gupta, Ghanshyam Das; Kumar, Vineet

doi:10.1007/s12247-020-09460-2

Cited by 76 publications

(37 citation statements)

References 28 publications

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“…Microneedle array patches have been under development for several decades. Early difficulties with manufacturing methodology and properties of the product have finally been overcome, and at least eleven products are now on the market [ 79 ]. The microneedles are long enough to traverse the stratum corneum, which causes no pain.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

Wertz

2021

IJMS

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PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin’s permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10–20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.

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Section: Transdermal Drug Deliverymentioning

confidence: 99%

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

Wertz

2021

IJMS

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“…In order to be considered a successful drug delivery system, the MN array patch must meet several criteria, such as [ 160 , 161 ]: insertion into the skin at sufficient depth without breaking, dimension and design with optimal properties, and using proper (biocompatible) material. …”

Section: Parameters Affecting the Mechanical Properties Of 3d Printed Microneedlesmentioning

confidence: 99%

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.

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“…11,18 The application of MN vaccine delivery systems for other diseases before the COVID-19 pandemic has been widely reviewed in the literature. 1,11,20 There have been numerous preclinical and clinical studies of vaccines using MN systems for a range of infectious diseases including influenza, BCG, MERS, polio, measles, rubella, hepatitis, and varicella zoster. [37][38][39][40][41][42][43] Of these, influenza has had the most robust studies, leading to currently commercially available MN vaccine delivery systems.…”

Section: Types Of Mns and Fabrication Techniquesmentioning

confidence: 99%

“…More recently, transdermal techniques have been under investigation for the COVID-19 vaccine, with several research groups showing early evidence of success in in vivo models. 20 , 21 The successful development of MN patch vaccines has significant implications for the future of vaccine delivery and the reduction in burden of disease of COVID-19. In this review, we discuss the challenges of existing vaccine modalities, the science behind transdermal delivery including MN patch technology, types of MNs and fabrication, current evidence of COVID-19 MN vaccine efforts, strengths and weaknesses of the MN approach, and considerations for implementation.…”

Section: Introductionmentioning

confidence: 99%

Transdermal approaches to vaccinations in the COVID-19 pandemic era

Lee

Pan

Nambudiri

2021

Therapeutic Advances in Vaccines and Immunotherapy

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The COVID-19 pandemic has necessitated rapid vaccine development for the control of the disease. Most vaccinations, including those currently approved for COVID-19 are administered intramuscularly and subcutaneously using hypodermic needles. However, there are several disadvantages including pain and fear of needlesticks, the need for two doses, the need for trained health care professionals for vaccine administration, and barriers to global distribution given the need for cold supply chain. Recently, transdermal techniques have been under investigation for vaccines including COVID-19. Microneedle array technology utilizes multiple microscopic projections from a plate which delivers a vaccine in the form of a patch placed on the skin, allowing for painless antigen delivery with improved immune response. In this review, we discuss challenges of existing vaccines and review the literature on the science behind transdermal vaccines including microneedles, current evidence of application in infectious diseases including COVID-19, and considerations for implementation and global access.

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Microneedle Array: Applications, Recent Advances, and Clinical Pertinence in Transdermal Drug Delivery

Cited by 76 publications

References 28 publications

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

Transdermal approaches to vaccinations in the COVID-19 pandemic era

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