Micromolar Concentrations of Neurotoxic Cations Induce Phase Separation, Aggregation and Fusion in Phosphatidylserine Containing Membranes

Deleers, Michel; Servais, Jean-Paul; Wülfert, Ernst

doi:10.1007/978-1-4613-2179-8_58

Cited by 2 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This procedure produced hydrophilic surfaces with a sessile water contact angle of 9.6 ± 3.5°. Treatment of the substrates with AlCl 3 was found to result in better transfer of lipid films, possibly by binding and stabilizing the lipid layer …”

Section: Methodsmentioning

confidence: 99%

Planar Supported Bilayer Polymers Formed from Bis-Diene Lipids by Langmuir−Blodgett Deposition and UV Irradiation

et al. 2003

View full text Add to dashboard Cite

Substrate-supported lipid bilayers have been prepared from bis-diene functionalized phosphorylcholine (PC) lipids and polymerized by UV irradiation. The overall bilayer structure is largely preserved upon removal from water, although significant loss of material occurs from the upper leaflet of the bilayer, likely due to desorption at the air/water interface. The morphology and surface structure of the bilayer, as observed by AFM, indicate a substantially different arrangement of the lipids in the hydrated and dehydrated states, presumably due to the loss of water from the near surface region. These changes have been correlated with infrared spectral shifts sensitive to the conformation of the hydrocarbon chains. Protein adsorption studies show that rehydrated, polymerized bilayers retain a degree of resistance to BSA adsorption intermediate between model hydrophobic and fluid PC lipid bilayer surfaces. The degree of protein adsorption is correlated with desorption of material from the upper leaflet of the bilayer upon drying, which produces voids at which hydrophobically driven protein adsorption occurs.

show abstract

Section: Methodsmentioning

confidence: 99%

Planar Supported Bilayer Polymers Formed from Bis-Diene Lipids by Langmuir−Blodgett Deposition and UV Irradiation

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Several studies concerning alterations in lipid composition [23,24], lipid peroxidation [25][26][27], and neuronal injury [28] following Al exposure have been reported. A number of in vitro [29][30][31] and in vivo studies [32] have shown that an increase in intraneuronal Al concentration potentates Fe-induced oxidative stress and might contribute to Al-facilitated oxidative injury, and thus to Al neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of low serum levels of Clara cell phospholipid-binding protein in occupational aluminium neurotoxicity

Hałatek

Sińczuk-Walczak

Rydzyński

2005

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

Micromolar Concentrations of Neurotoxic Cations Induce Phase Separation, Aggregation and Fusion in Phosphatidylserine Containing Membranes

Cited by 2 publications

References 6 publications

Planar Supported Bilayer Polymers Formed from Bis-Diene Lipids by Langmuir−Blodgett Deposition and UV Irradiation

Planar Supported Bilayer Polymers Formed from Bis-Diene Lipids by Langmuir−Blodgett Deposition and UV Irradiation

Prognostic significance of low serum levels of Clara cell phospholipid-binding protein in occupational aluminium neurotoxicity

Contact Info

Product

Resources

About