Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone

Shah, Furqan A.; Lee, Bryan; Tedesco, James V; Wexell, Cecilia Larsson; Persson, Cecilia; Thomsen, Peter; Grandfield, Kathryn; Palmquist, Anders

doi:10.1021/acs.nanolett.7b02888

Cited by 47 publications

(44 citation statements)

References 32 publications

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“…However, systemic driven HAP deposition can take place in the BrM, as reported before (Gorgels et al, 2012) (Alcolado et al, 1986). More recently, similarly structured spherules were also identified within patients with osteoporosis and in cardiovascular disease (Bertazzo et al, 2013;Shah et al, 2017). Thus, comparable mineralization mechanisms in a variety of non-osseous tissues appear to be associated with a number of different disease conditions.…”

Section: Hap Mineralization In the Retina Clearly Differs From Classimentioning

confidence: 53%

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

Bergen

Arya

Koster

et al. 2019

Progress in Retinal and Eye Research

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Retinal drusen formation is not only a clinical hallmark for the development of age-related macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and renal diseases. The initiation and growth of drusen is poorly and systemic side" of drusen. 6.2. Nineteen drusen proteins out of 89 were not assigned. 6.3. Blood proteins are an important source of drusen proteins. 7. Drusen and hydroxyapatite. 8. Drusen and plaques: age-related macular degeneration and atherosclerosis. 8.1. Clinical and epidemiological studies. 8.2. Histological and pathobiological similarities. 8.3. Genetics and molecular biology. 9. Future directions and conclusions.

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Section: Hap Mineralization In the Retina Clearly Differs From Classimentioning

confidence: 53%

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

Bergen

Arya

Koster

et al. 2019

Progress in Retinal and Eye Research

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“…Osteocytes are believed to be able to detect microdamage through ruptured osteocyte processes . Moreover, osteocyte lacunae (Ot.Lc) contribute toward cortical toughening through crack deflection, while occlusion of Ot.Lc by mineral deposition gives rise to isolated regions of lower strain‐to‐failure than the extracellular matrix . However, similar osteocyte densities as well as similar size and shape distributions (i.e., similar occupied area fraction) for all of the experimental groups suggests comparable biomechanical capacities in 16‐ and 20‐week‐old OVX and Ctrl animals.…”

Section: Discussionmentioning

confidence: 99%

Multiscale characterization of cortical bone composition, microstructure, and nanomechanical properties in experimentally induced osteoporosis

Shah

Stoica

Cardemil

et al. 2017

J Biomedical Materials Res

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Cortical bone plays a vital role in determining overall bone strength. We investigate the structural, compositional, and nanomechanical properties of cortical bone following ovariectomy (OVX) of 12-week-old Sprague Dawley rats, since this animal model is frequently employed to evaluate the performance of implantable biomaterials in compromised bone healing conditions. Morphological parameters and material properties of bone in the geometrical center of the femoral cortex were investigated four and eight weeks post-OVX and in unoperated controls (Ctrl), using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, Raman spectroscopy, and nanoindentation. The OVX animals showed increase in body weight, diminished bone mineral density, increased intracortical porosity, but increased bone mass through periosteal apposition (e.g., increases in periosteal perimeter, cortical cross-sectional thickness, and cross-sectional area). However, osteocyte densities, osteocyte lacunar dimensions, and the nanomechanical behavior on the single mineralized collagen fibril level remained unaffected. Our correlative multiscale investigation provides structural, chemical, and nanomechanical evidence substantiating earlier reports suggesting that rats ovariectomized at 12 weeks undergo simultaneous bone loss and growth, resulting in the effects of OVX being less obvious. Periosteal apposition contradicts the conventional view of bone loss in osteoporosis but appears advantageous for the greater functional demand imposed on the skeleton by increased body weight and fragility induced by increased intracortical porosity. Through a variety of morphological changes, it is likely that 12-week-old rats are able to adapt to OVX-related microstructural and compositional alterations. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 997-1007, 2018.

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“…The collagen crosslink ratio, taken as the % area of the 1662 cm −1 sub-component, corresponds to biochemically determined pyridinoline content and represents pyridinoline trivalent crosslinks-one of the several naturally occurring crosslinks in collagen [30]. Here, the collagen crosslink Phe levels decline with increasing tissue maturity [48] and are typically recorded at around 9-12% with respect to the intensity of the phosphate peak at 960 cm −1 [49,50] in periimplant bone. Here, Phe levels for Smokers (12-32%) and Ctrl (8-33%) were relatively higher, which reflects the contribution of rapidly formed woven bone.…”

Section: Discussionmentioning

confidence: 99%

Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

et al. 2019

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Smoking is a major risk factor for dental implant failure. In addition to higher marginal bone loss around implants, the cellular and molecular responses to injury and implant physicochemical properties are also differentially affected in smokers. The purpose of this work is to determine if smoking impairs bone microstructure and extracellular matrix composition within the dental alveolar socket after tooth extraction. Alveolar bone biopsies obtained from Smokers (> 10 cigarettes per day for at least 10 years) and Ctrl (never-smokers), 7-146 months after tooth extraction, were investigated using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, and Raman spectroscopy. Both Smokers and Ctrl exhibited high inter-and intra-individual heterogeneity in bone microstructure, which varied between dense cortical and porous trabecular architecture. Regions of disorganised/woven bone were more prevalent during early healing. Remodelled lamellar bone was predominant at longer healing periods. Bone mineral density, bone surface-to-volume ratio, mineral crystallinity, the carbonate-to-phosphate ratio, the mineral-to-matrix ratio, the collagen crosslink ratio, and the amounts of amino acids phenylalanine and proline/hydroxyproline were also comparable between Smokers and Ctrl. Bone microstructure and composition within the healing dental alveolar socket are not significantly affected by moderate-to-heavy smoking.

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Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone

Cited by 47 publications

References 32 publications

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

Multiscale characterization of cortical bone composition, microstructure, and nanomechanical properties in experimentally induced osteoporosis

Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

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