Micrometer-Scale Magnetic-Resonance-Coupled Radio-Frequency Identification and Transceivers for Wireless Sensors in Cells

Hu, Xiaolin; Aggarwal, Kamal; Yang, Mimi X.; Parizi, Kokab B.; Xu, Xiaoqing; Akin, Demir; Poon, Ada S. Y.; Wong, H.-S. Philip

doi:10.1103/physrevapplied.8.014031

Cited by 21 publications

(15 citation statements)

References 39 publications

(47 reference statements)

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“…We choose optical input-output (I/O) because the relevant optoelectronic components can readily be miniaturized to the microscale and read out remotely using far-field, free-space coupling. In contrast, devices based (50 μm) 2 on RF at this size (17)(18)(19)(20) are fundamentally limited to near-field coupling, requiring readers and power sources to be within less than a millimeter of the sensors (12). Ultrasound is also emerging as a promising approach, but to date the apparatus is specialized and the sensors have not been miniaturized to truly microscopic scales (12,13).…”

Section: Resultsmentioning

confidence: 99%

Microscopic sensors using optical wireless integrated circuits

Cortese

Smart

Wang

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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We present a platform for parallel production of standalone, untethered electronic sensors that are truly microscopic, i.e., smaller than the resolution of the naked eye. This platform heterogeneously integrates silicon electronics and inorganic microlight emitting diodes (LEDs) into a 100-μm-scale package that is powered by and communicates with light. The devices are fabricated, packaged, and released in parallel using photolithographic techniques, resulting in ∼10,000 individual sensors per square inch. To illustrate their use, we show proof-of-concept measurements recording voltage, temperature, pressure, and conductivity in a variety of environments.

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Section: Resultsmentioning

confidence: 99%

Microscopic sensors using optical wireless integrated circuits

Cortese

Smart

Wang

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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“…Figure 1 shows a rendering in which individual cells are tagged with the RFID tags. We 27 modeled, designed, and fabricated an aseptic version of this miniature wireless system using Taiwan Semiconductor Manufacturing Company (TSMC) 40 nm complementary metal–oxide–semiconductor (CMOS) technology 28 . The dimensions and design constraints are contingent on the size-dependent internalization rates of the RFIDs by cell, as previously revealed by Chen 29 .…”

Section: Resultsmentioning

confidence: 99%

Intracellular detection and communication of a wireless chip in cell

Yang

Akin

et al. 2021

Sci Rep

Self Cite

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The rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of an electronic device inside a cell. This is a significant forward step towards a vision of non-invasive, intracellular wireless platforms for single-cell analyses. We demonstrate that a 25 $$\upmu $$ μ m wireless radio frequency identification (RFID) device can not only be taken up by a mammalian cell but can also be detected and specifically identified externally while located intracellularly. The S-parameters and power delivery efficiency of the electronic communication system is quantified before and after immersion in a biological environment; the results show distinct electrical responses for different RFID tags, allowing for classification of cells by examining the electrical output noninvasively. This versatile platform can be adapted for realization of a broad modality of sensors and actuators. This work precedes and facilitates the development of long-term intracellular real-time measurement systems for personalized medicine and furthering our understanding of intrinsic biological behaviors. It helps provide an advanced technique to better assess the long-term evolution of cellular physiology as a result of drug and disease stimuli in a way that is not feasible using current methods.

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“…Compared with traditional bar codes, one of the biggest advantages is that the RFID tags can be embedded in objects that are being tracked, while not necessarily distributed on the surface of the objects. There have been many RFID-based sensors that can sense variable environmental parameters [ 11 , 12 ], including pipeline integrity and humidity, even on individual cell tracking and monitoring [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Microwave Backscatter-Based Wireless Temperature Sensor Fabricated by an Alumina-Backed Au Slot Radiation Patch

Wang

Guo

et al. 2018

Sensors

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A wireless and passive temperature sensor operating up to 800 °C is proposed. The sensor is based on microwave backscatter RFID (radio frequency identification) technology. A thin-film planar structure and simple working principle make the sensor easy to operate under high temperature. In this paper, the proposed high temperature sensor was designed, fabricated, and characterized. Here the 99% alumina ceramic with a dimension of 40 mm × 40 mm × 1 mm was prepared in micromechanics for fabrication of the sensor substrate. The metallization of the Au slot patch was realized in magnetron sputtering with a slot width of 2 mm and a slot length of 32 mm. The measured resonant frequency of the sensor at 25 °C is 2.31 GHz. It was concluded that the resonant frequency decreases with the increase in the temperature in range of 25–800 °C. It was shown that the average sensor sensitivity is 101.94 kHz/°C.

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Micrometer-Scale Magnetic-Resonance-Coupled Radio-Frequency Identification and Transceivers for Wireless Sensors in Cells

Cited by 21 publications

References 39 publications

Microscopic sensors using optical wireless integrated circuits

Microscopic sensors using optical wireless integrated circuits

Intracellular detection and communication of a wireless chip in cell

Microwave Backscatter-Based Wireless Temperature Sensor Fabricated by an Alumina-Backed Au Slot Radiation Patch

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