Abstract.A two-level homogenization approach is adopted in order to predict the stress state of deformed polycrystals in correlation with the microstructure. This study is devoted to complex loading paths behaviour of cubic material. A mechanical description of the grain is developed through a micro-meso transition based on elastoplastic Kröner's model. The meso-macro transition using a self-consistent approach is applied to deduce the global behaviour. Mechanical tests and neutron diffraction measurements are used to validate and assess the model.