Micromechanical cantilever as an ultrasensitive pH microsensor

Bashir, Rashid; Hilt, J. Zach; Elibol, Oğuz H.; Gupta, Amit; Peppas, Nicholas A.

doi:10.1063/1.1514825

Cited by 278 publications

(219 citation statements)

References 17 publications

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“…Recently, pH-assisted conformation change of HSA was examined using microcantilever sensors, which showed the possibility of detecting conformational change of HSA by variation of pH using nanomechanical bending [33]. This study and many previous reports show that microcantilever sensors have the potential to be sensitive micromechanical pH sensors [33][34][35][36].…”

Section: Introductionmentioning

confidence: 57%

Investigation of Ph-Assisted Human Serum Albumin (HSA)-Cobalt (Co)Binding Using Nanomechanical Deflection and Circular Dichroism

Kim¹

2011

J Nanomedic Nanotechnol

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Human serum albumin (HSA)-cobalt (Co) binding assay could serve as a marker for early detection of myocardial ischemia. However, the binding mechanism of the HSA-Co assay is very complex and hard to detect. During myocardial ischemia, the physiological pH may change with subsequent decrease in binding of Co with HSA. In this paper, we have investigated the binding of Co with HSA functionalized on the surface of microcantilever at acidic, basic and neutral pHs. Conformational change of HSA upon injection of Co(II) ions resulted in deflection of cantilever sensors. Furthermore, spectroscopic insight was obtained using circular dichroism to analyze conformational change of HSA-Co(II) binding.

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Section: Introductionmentioning

confidence: 57%

Investigation of Ph-Assisted Human Serum Albumin (HSA)-Cobalt (Co)Binding Using Nanomechanical Deflection and Circular Dichroism

Kim¹

2011

J Nanomedic Nanotechnol

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“…An example of this is the hydrogels employed as insulin delivery systems, which are capable of responding to the presence of glucose (Qiu and Park, 2001). These and other cleverly designed delivery devices have improved therapies for a wide variety of diseases (Qiu and Park, 2001;Bashir et al, 2002;Peppas and Kim, 2006).…”

Section: Constructing Non-mechanical Valves Using Bulk-triggered Respmentioning

confidence: 99%

Environmentally responsive polymeric "intelligent" materials: the ideal components of non-mechanical valves that control flow in microfluidic systems

Morones‐Ramírez¹

2010

Braz. J. Chem. Eng.

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-Miniaturization and commercialization of integrated microfluidic systems has had great success with the development of a wide variety of techniques in microfabrication, since they allowed their construction at a low cost and by following simple step-series procedures. However, one of the major challenges in the design of microfluidic systems is to achieve control of flow and delivery of different chemical reagents. This feature is especially important when using microfluidic systems in the development of cell culture systems, the construction of labs on a chip and the fabrication and design of chemical microreactors. Spatiotemporal control of the microenvironment in microfluidic devices has been only partially achieved by incorporating actuator parts (mechanical and non-mechanical) within these devices; nevertheless, recently there has been enormous progress due to advances in the materials sciences, and the development of novel polymeric "intelligent" materials. These materials have proved to be excellent candidates in the construction of non-mechanical actuators in the form of environmentally responsive valves. These valves can more efficiently control flows because these "intelligent" materials are capable of undergoing conformational changes and phase transitions in response to different local or external environmental stimuli; allowing them to turn the valves from "on" to "off". In addition, these valves have very simple designs, and are easy and cheap to incorporate into microfluidic systems. Therefore, although there are many reviews that focus on the development and design of non-mechanical actuators, the following review proceeds to describe the exciting characteristics, potential uses and synthesis methods of the building blocks of the most recent and innovative non-mechanical valves, environmentally responsive polymeric "intelligent" materials. In addition, the last section of this review will focus on the synthesis of composite materials that are capable of responding to more than one type of stimulus, since these materials are believed to be the future components that will boost the development of microfluidic systems with spatiotemporal controlled microenvironments.

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“…(7) Among the subjects investigated, a pH test has great significance, not only for field measurements but also in lab experiments, because a large number of chemical and biological processes depend on pH. There are many techniques that can be used to detect pH values, such as pH image sensors, (8) glass electrodes, (9) conductimetric pH sensors, (10) cantilevers, (11) optical fiber pH sensors, (12) and ion-sensitive field-effect transistor (ISFET)-based pH sensors. (13) Each experimental approach has its own merits and drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Developing a Solid-State pH Sensor for Wagyu-Rumen Monitoring

2016

Sensors and Materials

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We have developed a solid-type pH sensor for dairy wagyu-rumen measurements. The pH sensor is composed of a sensing electrode of indium tin oxide (ITO) film and a metal-oxidesemiconductor field-effect transistor (MOSFET). In the solid-state sensor structure, the ITO electrode is a separated gate of the FET and the ITO electrode can be patterned with a suitable capture structure for the wagyu-rumen environment. A sensor system with a compact size can be fabricated by eliminating the reference solution. The pH sensors have a sensitivity of 10-15 µA/pH under different sensing contact areas from 12 to 78 mm 2 . Long-term tests with interval experiments have been completed in 18 d, and the results demonstrate that the pH sensor has a stable performance for rumen pH measurements over a long time.

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Micromechanical cantilever as an ultrasensitive pH microsensor

Cited by 278 publications

References 17 publications

Investigation of Ph-Assisted Human Serum Albumin (HSA)-Cobalt (Co)Binding Using Nanomechanical Deflection and Circular Dichroism

Investigation of Ph-Assisted Human Serum Albumin (HSA)-Cobalt (Co)Binding Using Nanomechanical Deflection and Circular Dichroism

Environmentally responsive polymeric "intelligent" materials: the ideal components of non-mechanical valves that control flow in microfluidic systems

Developing a Solid-State pH Sensor for Wagyu-Rumen Monitoring

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