The full-wave characterization of reconfigurable antenna sensors for non-invasive detection of melanoma is presented. To this end, an enhanced locally conformal finitedifference time-domain numerical procedure, based on a suitable normalization of the electromagnetic field-related quantities, is adopted. In this way, a physical insight in wave diffraction phenomena occurring in the radar monitoring of skin cancers, as well as in the natural resonant processes responsible for the performance of the considered class of devices is achieved. This, in turn, is important in order to enhance the device reliability, so optimizing the design cycle. In this respect, a suitable microelectro-mechanical-system-based sensor layout is proposed.