Micromachined sensor for lactate monitoring in saliva

Schabmueller, C G J; Loppow, D; Piechotta, G.; Schütze, Berit; Albers, Jörg; Hintsche, R.

doi:10.1016/j.bios.2005.09.015

Cited by 53 publications

(50 citation statements)

References 15 publications

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“…These changes in salivary total protein concentration might have been elicited in response to sympathetic activation, and we speculate that they also aff ect blood lactate concentration, which may explain the correlation between salivary and lactate thresholds [21] . Previous work measured lactate in saliva [28] as an alternative to its measurement in blood [31] , but one disadvantage of this technique is that oral mucosa is bacteria-rich, and once exposed to air, bacteria produce lactate because of the inactivation of pyruvate formate-lyase, which catalyzes the fi rst step of pyruvate conversion to formate, acetate and ethanol [19] . Such a scenario could render this method inaccurate for determining exercise-induced lactate production.…”

Section: Discussion ▼mentioning

confidence: 99%

Changes in the Salivary Biomarkers Induced by an Effort Test

et al. 2010

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Physical exercise induces biochemical changes in the body that modify analytes in blood and saliva among other body fluids. This study analyzed the effect of an incremental effort test on the salivary protein profile to determine whether any specific protein is altered in response to such stress. We also measured thresholds of salivary alpha amylase, total salivary protein and blood lactate and searched for correlations among them. Twelve male cyclists underwent a progressive test in which blood and saliva samples were collected simultaneously at each stage. The salivary total protein profile revealed that physical exercise primarily affects the polypeptide corresponding to salivary alpha-amylase, the concentration of which increased markedly during the test. We observed thresholds of salivary alpha-amylase (sAAT), total salivary protein (PAT) and blood lactate (BLT) in 58%, 83% and 100% of our sample, respectively. Pearson's correlation indicates a strong and significant association between sAAT and BLT (r= 0.84, P<0.05), sAAT and PAT (r= 0.83, P<0.05) and BLT and PAT (r= 0.90, P<0.05). The increased expression of the salivary alpha-amylase (sAA) polypeptide suggests that sAA is the main protein responsible for the increase in total protein concentration of whole saliva. Therefore, monitoring total protein concentration is an efficient tool and an alternative noninvasive biochemical method for determining exercise intensity.

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Section: Discussion ▼mentioning

confidence: 99%

Changes in the Salivary Biomarkers Induced by an Effort Test

et al. 2010

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“…It is also essential to measure CBL levels among diabetics due to the close metabolic relationship between glucose and lactate [36, 37]. Besides that, analysis of CBL concentration is of high interest in sports medicine for athletes to tailor their training in order to optimise their performance [38, 39]. For instance, it is important to determine the anaerobic threshold (AT) or maximum lactate steady state (MLSS) from the lactate load curves during exercise, which is the maximum load when lactate production is in equilibrium with lactate elimination.…”

Section: Salivary Lactatementioning

confidence: 99%

“…For instance, it is important to determine the anaerobic threshold (AT) or maximum lactate steady state (MLSS) from the lactate load curves during exercise, which is the maximum load when lactate production is in equilibrium with lactate elimination. Based on the AT, suitable exercise intensity can be precisely given to the athletes for different types of sports in order to produce optimal results [38]. …”

Section: Salivary Lactatementioning

confidence: 99%

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Malon

Sadir

Malarvili

et al. 2014

BioMed Research International

183

108

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Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.

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“…IrOx is mainly known as pH electrode (Carroll and Baldwin, 2010;Wang et al, 2002;Yao et al, 2001). However, in solutions with known pH it can be used as pseudo-reference electrode (Li et al, 2009;Schabmueller et al, 2006;Yang et al, 2004). The major benefit of using IrOx is that it can withstand much higher temperatures (Midgley, 1990), which is especially important for chip fabrication.…”

Section: Introductionmentioning

confidence: 97%