Micromachined Polymeric Devices for Applications in Targeted Drug Delivery

Tao, Sarah L.; Desai, Tejal A.

doi:10.1016/j.jala.2004.04.017

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…At the micron scale, Desai et al explored the use of microfabrication techniques for synthesizing biocapsules for immunoisolation of “drug” releasing cell transplants [43, 44]. They also studied photolithography for fabricating shape-specific drug delivery micro-devices and particles [45–48]. For instance, the group demonstrated the fabrication of multilayered microparticles that can be released from the substrate by selective etching of a sacrificial layer [46, 48, 49].…”

Section: Shape and Size Specific Nanocarriersmentioning

confidence: 99%

Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

Caldorera‐Moore

Guimard

Shi

et al. 2010

Expert Opinion on Drug Delivery

266

185

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Importance of the field-Although significant progress has been made in delivering therapeutic agents through micro and nanocarriers, precise control over in vivo biodistribution and diseaseresponsive drug release has been difficult to achieve. This is critical for the success of next generation drug delivery devices, since newer drugs, designed to interfere with cellular functions, must be efficiently and specifically delivered to diseased cells. The major constraint in achieving this has been our limited repertoire of particle synthesis methods, especially at the nanoscale. Recent developments in generating shape-specific nanocarriers and the potential to combine stimuliresponsive release with nanoscale delivery devices show great promise in overcoming these limitations.Areas covered in this review-Here we discuss how recent advancements in fabrication technology allow synthesis of highly monodisperse, stimuli-responsive, drug-carrying nanoparticles of precise geometries. We also review how particle properties, specifically shape and stimuli responsiveness, affect biodistribution, cellular uptake, and drug release.What the reader will gain-The reader is introduced to recent developments in intelligent drug nanocarriers and new nanofabrication approaches that can be combined with disease-responsive biomaterials. This will provide insight into the importance of controlling particle geometry and incorporating stimuli responsive materials into drug delivery.

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Section: Shape and Size Specific Nanocarriersmentioning

confidence: 99%

Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

Caldorera‐Moore

Guimard

Shi

et al. 2010

Expert Opinion on Drug Delivery

266

185

View full text Add to dashboard Cite

show abstract

“…[ 46 ] One simple and widely used method for aminating a polymeric surface or microstructure involves immersing it into a solution of an aminating agent dissolved in an organic solvent, such as EDA-in-ethanol. [ 2,4,5,7,11,[14][15][16]19,25,27,35 ] Although it is well established that treatment with ethanolic EDA and related methods are effective for aminating surfaces, little attention has been devoted to how these processes affect the form and integrity of a microstructure. Altering the form of a microstructure can dramatically affect its performance, so it is important to understand what structural changes may result with a given surface functionalization process and to identify improved alternatives.…”

Section: Introductionmentioning

confidence: 99%

“…[ 24 ] Polymeric microstructures can also be chemically functionalized to imbue specifi c chemical, mechanical, or physical properties. Amine-functionalized surfaces and microstructures have applications in tissue engineering, [ 25 ] microfl uidics, [26][27][28] microelectromechanical systems, [ 29 ] DNA-and protein-microarrays, [ 30,31 ] nanowire and nanotube sensors, [ 32 ] lab-on-a-chip platforms, [ 33 ] systems for high-throughput drug discovery, [ 34 ] drug delivery systems, [ 35 ] and functional nanophotonic structures. [ 4,5 ] SU-8 is a photo-crosslinkable epoxide oligomer that is increasingly used to create functional 2D and 3D microscale S. M. Kuebler et al…”

mentioning

confidence: 99%

Low‐Distortion Surface Functionalization of Polymeric Microstructures

Kuebler

Narayanan

Karas

et al. 2014

Macro Chemistry & Physics

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Polymeric microstructures can be immersed in an organic solution containing a reactive linker to functionalize the surface for attachment of nanoparticles, fluorescent dyes, proteins, DNA, and other species. However, organic media can swell and distort polymeric microstructures. Swelling and distortion can be irreversible when the linkers are themselves low‐molecular‐weight organics like ethylenediamine, which can bind to unreacted monomer groups or other functionalities within the polymer matrix. This work introduces an alternative approach for surface functionalization based on aqueous processing using higher‐molecular‐weight amines, which causes less distortion, but is comparably effective. The processes are compared by aminating crosslinked SU‐8 thin films and 3D “woodpile” microstructures, electrolessly depositing copper onto these primed surfaces, and measuring the amount of copper deposited and the degree of distortion caused by amination. The method provides a new route to low‐distortion SU‐8 microstructures and identifies a path for improving related processing with other polymeric materials and structure types.

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“…1a). To improve the controlled release techniques, innovative drug delivery technologies 1 –3 have become extremely important in the pharmaceutical development. Among these, one popular technique is characterized by using micro-electromechanical system (MEMS) technologies, in which microneedles 4 –6 and implantable microchips 7 are used.…”

Section: Introductionmentioning

confidence: 99%

Microfabrication of Bilayer Polymer Actuator Valves for Controlled Drug Delivery

Tsai

Madou

2007

JALA: Journal of the Association for Laboratory Automation

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D rug delivery is still a challenging mission in therapeutic treatment. Research on biomedical micro-electromechanical systems (BioMEMS) has led to a diverse range of microsystems for curative applications. This paper introduces miniaturized controlled valves and drug reservoirs for drug delivery systems. Detailed microfabrication processes, optimized package, and optical/electrochemical detection of the proposed device are described. The release mechanism of the device is controlled by a bilayer actuator valve, which consists of a conductive polymer polypyrrole (PPy) film and a thin metal gold (Au) layer. The PPy layer is electrochemically polymerized on the Au layer. Therefore, further miniaturization of the device is possible through microfabrication of the Au layer. A polydimethylsiloxane (PDMS) package is also introduced to prevent the flap from being blocked by the surrounding tissue of the human body. In addition, a parylene coating is applied to minimize the permeability of PDMS. The release process is then verified by an optical and electrochemical detection system. (JALA 2007;12:291-5)

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Micromachined Polymeric Devices for Applications in Targeted Drug Delivery

Cited by 4 publications

References 10 publications

Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

Low‐Distortion Surface Functionalization of Polymeric Microstructures

Microfabrication of Bilayer Polymer Actuator Valves for Controlled Drug Delivery

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