Microinjections of d-amphetamine into the nucleus accumbens and caudate-putamen differentially affect stereotypy and locomotion in the rat

Staton, Donna M.; Solomon, Paul R.

doi:10.3758/bf03332184

Cited by 154 publications

(57 citation statements)

References 19 publications

(20 reference statements)

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“…Originally, we expected that performance would deteriorate under a DA agonist given that (1) DA agonists can worsen psychotic symptoms in patients with schizophrenia (Davidson et al, 1987;Abi-Dargham et al, 1998) and trigger psychotic symptoms in healthy participants (Janowsky and Risch, 1979;Sekine et al, 2001); (2) schizotypy and schizophrenia share cognitive (Gooding et al, 1999;Park, 1999), attentional (Sarkin et al, 1998;Mohr et al, 2003a), behavioral (Barnett and Corballis, 2002;Mohr et al, 2003b), and physiological (Klein et al, 1999;Pizzagalli et al, 2000) similarities; and (3) DA agonists increase stereotyped responding in animals (Randrup and Munkvad, 1974;Staton and Solomon, 1984;Kelley et al, 1988) and healthy populations (Connell, 1958;Ridley et al, 1988). Findings from animal (Arnsten, 1997;Williams and Goldman-Rakic, 1995) and human (Mehta et al, 2000) studies propose that dopaminergic actions follow an inverted Ushape function, with an improvement of cognitive performance from low to medium, but deterioration from medium to high doses.…”

Section: Discussionmentioning

confidence: 99%

“…As known from the animal literature, the administration of DA agonists can trigger stereotyped behavior (Staton and Solomon, 1984;Kelley et al, 1988;Kuczenski and Segal, 1999), particularly after high doses (Randrup and Munkvad, 1974). It is thus not a surprise that stereotyped behavior is observed in patients with schizophrenia (Kraeplin, 1919;Bleuler, 1911Bleuler, / 1950Jones, 1965;Peralta and Cuesta, 2001) and in healthy persons after amphetamine abuse (Connell, 1958, Ridley et al, 1988.…”

Section: Introductionmentioning

confidence: 99%

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Nonstereotyped Responding in Positive Schizotypy after a Single Dose of Levodopa

Möhr

Landis

Sándor

et al. 2004

Neuropsychopharmacol

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Stereotyped behavior and left-sided orientation biases, associated with the dopamine (DA) system, were observed in populations of the schizophrenia spectrum disorders. We investigated whether heightened DA concentrations influence both side biases and stereotyped responding in a visuo-motor computer task, in which 90, 180, and 2701 rotated objects had to be brought into a target position. To account for the role of the schizophrenia spectrum, task performance was also analyzed as a function of healthy participants' high or low magical ideation (MI), a positive schizotypal feature. The first 36 participants (20 women) remained substance free. In a second sample, 20 men received levodopa and 20 men a placebo in a double-blind procedure. Results showed that high MI scorers responded more stereotyped than low MI scorers, without being specifically biased towards the left side. Rotation preferences toward one or the other side made high MI scorers less flexible for objects efficiently to be rotated into the opposite direction. This inflexibility may reflect impaired left hemisphere functioning. Unexpectedly, in the levodopa group, high MI scorers performed superior to low MI scorers. Since DA actions appear to follow an inverted U-shape function, the 'low' performing high MI scorers profited from the enhanced DA availability. Our observation in the levodopa group points to a dissociation between schizotypy and schizophrenia: while cognitive improvement in schizophrenia can occur after treatment with atypical neuroleptic agents, in our positive schizotypal participants a DA agonist resulted in improved task performance. This dissociation may point to protective neurochemical mechanisms preventing healthy schizotypes from developing full-blown psychotic symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nonstereotyped Responding in Positive Schizotypy after a Single Dose of Levodopa

Möhr

Landis

Sándor

et al. 2004

Neuropsychopharmacol

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“…This suggests that DA in NAc mediates hyperlocomotion, whereas DA in the dorsal striatum mediates stereotypies. In fact selective injections of amphetamine within the NAc [103] as well as in the ventrolateral striatum [104] induce hyper-locomotion, whereas injections in the dorsal striatum produce stereotypies [104-106]. …”

Section: Methamphetamine-induced Behavioural Effectsmentioning

confidence: 99%

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Ferrucci

Giorgi

Bartalucci

et al. 2013

Current Neuropharmacology

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The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

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“…Such a biphasic profile is not surprising. Indeed, following repeated administration of high AMPH dosages, adult rodents usually exhibit sensitization of stereotyped behavioral activity (Staton and Solomon 1984;Stewart and Badiani 1993). It can be hypothesized that the excessive arousal, repeatedly induced by high AMPH dosages during the pretreatment phase, might have produced, together with observable stereotypies, unobservable aversive effects ("poor welfare," see Laviola et al 1994Laviola et al , 1995Laviola and Adriani 1998), which were associated with the drug-paired compartment.…”

Section: Amph-induced Place Conditioningmentioning

confidence: 99%

Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice Evidence of Dissociation as a Function of Age at Weaning

Adriani

Laviola

2002

Neuropsychopharmacology

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Individual differences in coping with novelty and in the response to psychoactive drugs have been related to early life events, such as the age of weaning. Outbred CD-1 mice underwent a precocious (postnatal day (pnd) Apart from the individual genetic background, individual differences in the seeking for novelty and in vulnerability to drug abuse may also be the consequence of critical experiences occurring early in life. There is indeed a growing literature investigating the effects of precocious manipulations upon brain and behavioral regulations in animal models (for a review, see Laviola and Terranova 1998). In this context, the gradual transition to nutritional and behavioral independence, which NO . 2 takes place at weaning, can well be seen as a centerpiece in development. This is a period of neural and behavioral organization, and hence a potential vulnerability of CNS structures can be hypothesized (Greenough et al. 1990). Moreover, whereas the date of weaning is fixed in most rodent studies around the end of the third postnatal week, weaning is a gradual phenomenon under natural conditions (Galef 1981). Individual differences in the process of separation from the mother might lead to hormonal and behavioral consequences that contribute to the natural variability of phenotypes (Cirulli et al. 1997).Experimental manipulation of weaning time in cats and rats has been shown to affect a wide range of facets of the adult behavioral repertoire: specifically, it has been suggested that pups may adaptively respond to precocious weaning by speeding up subsequent development (Bateson et al. 1990). Accordingly, when compared with a regular weaning group, animals weaned precociously show a number of behavioral (Martin and Bateson 1985;Terranova and Laviola 1995;Loggi et al. 1996;Terranova et al. 2000) and neurochemical (see e.g. Sharman et al. 1982;Mann and Sharman 1983) changes, which can be regarded as signs of advanced ontogeny. Conversely, it has been shown that weaning itself acts as a developmental stimulus for the expression and onset of functional control of a specific opioid receptor (delta subpopulation), and that a late weaning may delay such development (Muhammad and Kitchen 1993;Kitchen et al. 1994; see also Terranova and Laviola 2001). Dopaminergic CNS systems have been reported to undergo maturation during the pre-and post-weaning period (Rao et al. 1991;Teicher et al. 1995;Moll et al. 2000). The individual organization of this neurobehavioral system might hence be affected by an early or a delayed separation from the lactating dam. Indeed, age at weaning is reported to affect the development of the dopaminergic system as well as the response to dopaminergic drugs (Cirulli et al. 1997;Laviola & Dell'Omo 1997).It has been recently suggested that the activation of brain mesolimbic pathways, which are involved in reward-related phenomena and motivation (Robbins and Everitt 1996;Wise 1996), share a common neurobiological substrate with the active search of novelty and other natural rewarding sensati...

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Microinjections of d-amphetamine into the nucleus accumbens and caudate-putamen differentially affect stereotypy and locomotion in the rat

Cited by 154 publications

References 19 publications

Nonstereotyped Responding in Positive Schizotypy after a Single Dose of Levodopa

Nonstereotyped Responding in Positive Schizotypy after a Single Dose of Levodopa

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice Evidence of Dissociation as a Function of Age at Weaning

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