Microheterogeneity of alpha₁‐acid glycoprotein in the detection of intercurrent infection in patients with rheumatoid arthritis

Abstract

It has been firmly established that there is a higher rate of mortality associated with infection

Changes in Acute-Phase Proteins during Lithium Potentiation of Antidepressants in Refractory Depression

“…After 4 weeks of Li potentiation they had higher values of AGP-RC than Li responders and showed less decrease of elevated AGP concentrations. The type I changes of glycosylation (high values of AGP-RC and high concentrations of AGP), found in nonresponders, were observed in patients with burns, with rheumatoid arthritis and lupus erythematosus with intercurrent infection [35], Glucocorticoids modu late the effects of cytokines on synthesis rates and espe cially on glycosylation of APPs [26,36]. In our previous study, a significant positive correlation between morning cortisol levels and levels of AGP was found in depressed patients [37].…”

Changes of α1-acid glycoprotein microheterogeneity in acute inflammation stages analyzed by isoelectric focusing using serum obtained postoperatively

“…According to these reports, Con Areactive dibranched oligosaccharide chains of AGP increase in the sera of early-stage acute inflammation patients [14,16,17,23]. The serum levels of this type of AGP reached a maximum on about the second day after operation, which gradually decreased to normal level in about 15 days [21].…”

“…Microheterogeneity of the number of branched oligosaccharide chains is determined by crossed affinoimmunoelectrophoresis (CAIE) of AGPs with free concanavalin A (Con A) in the first dimension, which has been reported in a number of diseases [14±20]. Using CAIE, Con A-reactive dibranched oligosaccharide chains of AGP increase in the sera of early-stage acute inflammation patients [14,16,17] but decrease in the sera of chronic inflammation patients. Examples are severe rheumatoid arthritis [14,15], alcoholic liver cirrhosis [19], pulmonary sarcoidosis [18], and osteoarthritis [20].…”

Changes of glycosylation of serum proteins in psoriatic arthritis, studied by enzyme‐linked lectin assay (ELLA), using concanavalin A

“…Although the biological significance of the changes of glycosylation of serum proteins in various rheumatic diseases (1-10) is still unknown (11), several investigators indicated their usefulness for diagnostic purposes (2,5,(12)(13)(14)(15)(16).…”