Microheterogeneity and polymorphism of human serum thyroxine-binding globulin study by isoelectric focusing and radioprint immunofixation

Lasne, Y; Lasne, Françoise; Benzerara, O.

doi:10.1016/0005-2795(80)90074-4

Cited by 11 publications

(1 citation statement)

References 8 publications

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“…Some differences in the relative distribution of TBG subspecies were found in the present studies, but there was no correlation be¬ tween TBG patterns and either TBG concentration or serum 'inhibitory activity'. It is therefore more likely that these interindividual differences corres¬ pond to TBG polymorphism, found in normal individuals (Lasne et al 1980), rather than to the presence of circulating dTBG.…”

Section: Discussionmentioning

confidence: 98%

Absence of circulating desialylated thyroxine-binding globulin in patients with hepatobiliary disease

Costante

Sand

Reding

et al. 1985

Acta Endocrinologica

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Thyroxine-binding globulin (TBG) is the major thyroid hormone carrier protein. The molecule contains approximately 10 sialic acid residues which play a key role in the peripheral metabolism of TBG. Since the serum of patients with liver disease often contains large amounts of several desialylated glycoproteins, the aim of the present studies was to characterize circulating TBG and to examine the possible presence of desialylated TBG (dTBG) in 24 patients with a variety of hepatobiliary diseases and selected on the basis of elevated serum levels of desialylated glycoproteins. Using 4 immunochemical techniques applied for the measurement of TBG, for the detection of dTBG and for the characterization of TBG microheterogeneity, the results indicated: a) a wide scatter of serum TBG levels between 4 and 23 mg/l; b) the absence of detectable amounts of dTBG in any of the sera tested; and c) a close similarity between the microheterogeneity of TBG in patients with liver disease with that of control sera or of purified TBG. In conclusion, in patients with acute and chronic liver disease, TBG, although quantitatively modified, remains qualitatively unaltered, suggesting that diseased liver produces fully sialylated TBG and that its catabolism is not impaired.Requests for reprints:

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Section: Discussionmentioning

confidence: 98%

Absence of circulating desialylated thyroxine-binding globulin in patients with hepatobiliary disease

Costante

Sand

Reding

et al. 1985

Acta Endocrinologica

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A new polymorphism of thyroxin-binding globulin in three African groups (Mali) with endemic nodular goitre

et al. 1992

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The thyroxin-binding globulin (TBG) polymorphism was investigated in three African groups: two belonged to the Bwa villages of Mali, and the third was a Dogon group living in the same area. The Bwa groups were characterized by the occurrence of nodular goitres, whereas the Dogon population did not show similar pathological symptoms. Females were more affected by goitre than males in the affected villages. The TBG polymorphism enabled us to demonstrate the presence of an undescribed allele (TBG C1) in these populations. The frequency of the TBG S allele was also higher than previously published in other African groups. We observed a disequilibrium in the distribution of the C and S alleles in the population, with an excess of homozygous TBG S individuals. No clear relationship between the TBG polymorphism and the number of nodules can be drawn.

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Studies on thyroxine-binding globulin

Bartalena

1993

J Endocrinol Invest

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Microheterogeneity and polymorphism of human serum thyroxine-binding globulin study by isoelectric focusing and radioprint immunofixation

Cited by 11 publications

References 8 publications

Absence of circulating desialylated thyroxine-binding globulin in patients with hepatobiliary disease

Absence of circulating desialylated thyroxine-binding globulin in patients with hepatobiliary disease

A new polymorphism of thyroxin-binding globulin in three African groups (Mali) with endemic nodular goitre

Studies on thyroxine-binding globulin

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