Microheated substrates for patterning cells and controlling development

Shu, Wenmiao; Everett, W. Neil; Zhang, Q.X.; Liu, M.H.; Trigg, A. D.; Ma, Yuexia; Spearing, S.M.; Wang, Shu; Sue, Hung‐Jue; Moran, P.M.

doi:10.1109/jmems.2005.856677

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…Microheaters have been used independently (i.e., without a chemical sensor or electrode) for temperature control in aqueous systems for a range of studies including bubble nucleation and growth [17,18], DNA amplification [19][20][21], cell culture and growth [22,23], and other microfluidic applications [24]. However, microheaters have only infrequently been coupled to solution-phase sensors.…”

Section: Introductionmentioning

confidence: 99%

Thermal characteristics of temperature-controlled electrochemical microdevices

Contento

Semancik

2016

Sensors and Actuators B: Chemical

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The development of novel, miniaturized sensing systems is driven by the demand for better and faster chemical measurements with lower power consumption and smaller sample sizes. Emerging miniature sensors, or microsensors, also offer rapid thermal and diffusive transport characteristics. For instance, temperature changes, during both heating and cooling, can be achieved on micrometer-scale surfaces much more rapidly than on bulk, macro-scale surfaces. While these rapid thermal characteristics have been most successfully exploited to date in gasphase sensing devices, the prospect of developing analogous microfabricated, temperaturecontrolled microsensors for use in aqueous, or solution-phase, environments has been less explored. In this work, electrodes with underlying microheaters were designed and fabricated, and thermal characterization was performed using temperature imaging, transient temperature measurements, and theoretical modeling to determine temperature distributions and thermal response times in both gas-and solution-phase environments. These results will guide the development of solution-phase electrochemical sensors. Temperature-controlled electrochemical characterization was performed using cyclic voltammetry of a model analyte, hexaamineruthenium(III) chloride, to demonstrate the use of the multilayer, microfabricated devices, which consisted of a gold disk electrode and an underlying microheater. Electrochemical signals were enhanced by up to a factor of three at elevated temperatures (up to 81 °C) compared to the those measured at room temperature (21 °C). This improved signal at elevated temperatures was explained by finite element method calculations that accounted for both temperature-dependent diffusion and thermal convection near the heated electrode surface.

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