Micrographic surgey for the treatment of non-melanoma skin cancers of the head and neck

Elçin, Gonca; Özer, Serdar; Gököz, Özay; Yücel, Ömer Taşkın; Özaygen, Gül Erkin; Akan, Tülin

doi:10.4274/turkderm.23334

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Tubingen technique was reported in the most recent RCT, 33 in a non‐randomized controlled study 34 and six non‐randomized and non‐controlled studies 35–40 . The Munich technique was reported in three non‐randomized and non‐controlled studies 41–43 and the Muffin technique in only one 44 …”

Section: Resultsmentioning

confidence: 99%

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Recurrence rate of basal cell carcinoma among different micrographic surgery techniques: systematic review with meta‐analysis

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Luna

et al. 2022

Acad Dermatol Venereol

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In high-risk basal cell carcinomas (BCCs), micrographic surgery (MS) has high tissue preservation and low recurrence rates. The Mohs technique is the most commonly used technique, with limited use of other MS techniques. No studies have been designed to compare the MS methods. This review aimed to assess BCC recurrence rates of different MS techniques. A systematic review and meta-analysis were conducted to search for related studies in PubMed, LILACS, EMBASE, SCOPUS, WEB OF SCIENCE, CINHAL and COCHRANE until March 2021. Randomized clinical trials (RCTs) and observational studies involving patients with BCC and indications for different MS techniques were included. Study selection and data extraction were performed independently by three peer reviewers, as was the risk of bias assessment using the Joanna Briggs Institute tool. Pooled estimates were assessed using the random-effects model (Logit), and heterogeneity was assessed by the chi-squared test (v 2 ). Stata Software version 17.0 was used for analysis. Eighteen studies were included, two RCTs and sixteen observational studies. The overall recurrence rate was 2% (95% CI, 1.0-3.0%; v 2 = 46.2; P = 0.00; 18 studies, 10 424 BCCs). In studies using the Mohs technique, the recurrence rate was 3.0% (95% CI, 1.0-5.0%; v 2 = 11.0; P = 0.00; 6 studies; 1,582 BCCs), with the Munich technique 3.0% (95% CI, 2.0-5.0%; v 2 = 0.0; no heterogeneity; 3 studies; 404 BCCs), with Tubingen technique 1% (95% CI, 1.0-2.0%; v 2 = 12.1; P = 0.00; 8 studies; 8374 BCCs) and with the Muffin technique 0.0% (95% CI, 0.0-6.0%; 1 study; 64 BCCs). Relapse rates between MS techniques were low and appeared to be similar. However, the design of this review and the absence of primary studies that directly compare the techniques do not allow us to assert the superiority between them.

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Section: Resultsmentioning

confidence: 99%

“…The diameter of tumours subjected to MS ranged from 9 to 15 mm and the mean follow‐up of the included studies was 59 months (range, 23–120 months). Adverse events were reported in only two studies, with no complications related to the surgical technique 43,44 …”

Section: Resultsmentioning

confidence: 99%

Recurrence rate of basal cell carcinoma among different micrographic surgery techniques: systematic review with meta‐analysis

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Lange

Luna

et al. 2022

Acad Dermatol Venereol

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Comparison of anti-TNF and IL-inhibitors treatments in patients with psoriasis in terms of response to routine laboratory parameter dynamics

Ataseven

Temiz

Eren

et al. 2020

Journal of Dermatological Treatment

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Background: Biological agent treatments represent a relatively new field and their effects on routine laboratory parameters are not fully known as there has been little research in the area. In our study, we aimed to evaluate the differences between the two main biological treatment groups and their effects on routine laboratory parameters. Methods: Patients were enrolled when they had received treatment for more than six months with biological treatments between January 2013 and April 2020. The available data on routine laboratory parameters were collected by routine blood tests before the treatment, at three months, and at the final evaluation. Results: When the changes in routine laboratory parameters were evaluated by treatment, it was found that the NLR and CRP values decreased statistically significantly in the anti-TNF group compared to the IL inhibitor group. In addition, strong suppression of these inflammation parameters means strong suppression of the immune system response. In addition, AST, ALT, and creatinine values were found to be statistically significantly higher in the anti-TNF group compared to the IL inhibitor group. Conclusions: In our study, anti-TNF treatments are shown to be more effective in reducing inflammation parameters while IL antagonists are safer in terms of biochemical parameters.

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Micrographic surgey for the treatment of non-melanoma skin cancers of the head and neck

Cited by 2 publications

References 6 publications

Recurrence rate of basal cell carcinoma among different micrographic surgery techniques: systematic review with meta‐analysis

Recurrence rate of basal cell carcinoma among different micrographic surgery techniques: systematic review with meta‐analysis

Comparison of anti-TNF and IL-inhibitors treatments in patients with psoriasis in terms of response to routine laboratory parameter dynamics

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