Microglial Piezo1 mechanosensitive channel as a therapeutic target in Alzheimer’s disease
Erol D. Ikiz,
Erin R. Hascup,
Chilman Bae
et al.
Abstract:Microglia are the resident macrophages of the central nervous system (CNS) that control brain development, maintain neural environments, respond to injuries, and regulate neuroinflammation. Despite their significant impact on various physiological and pathological processes across mammalian biology, there remains a notable gap in our understanding of how microglia perceive and transmit mechanical signals in both normal and diseased states. Recent studies have revealed that microglia possess the ability to dete… Show more
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