Microglial-Mediated Prevention of Axonal Degeneration in the Injured Spinal Cord: Insights from anIn VivoImaging Study
Wanjie Wu,
Yingzhu He,
Yujun Chen
et al.
Abstract:Microglia, the primary immune cells in the central nervous system, play a critical role in regulating neuronal function and fate through their interaction with neurons. Despite extensive research, the specific functions and mechanisms of microglia-neuron interactions remain incompletely understood. In this study, we demonstrate that microglia establish direct contact with myelinated axons at Nodes of Ranvier in the spinal cord of mice. Under normal physiological conditions, microglia-node contact occurs in a r… Show more
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