Microglial Activation: Key Players in SepsisAssociated Encephalopathy
Jiyun Hu,
Shucai Xie,
Haisong Zhang
et al.
Abstract:Sepsis-associated encephalopathy (SAE) is a common brain dysfunction following sepsis that often results in severe cognitive and neurological sequelae and increases the mortality rate in patients with sepsis. Microglia are resident macrophages in the brain that play essential roles in the pathological and physiological processes of SAE. Depending on the nature of the stimulus, microglia can adopt two polarization states (M1/M2), which correspond to altered microglial morphology, gene expression, and function. … Show more
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