“…In AD, it has been shown that microglia recognize soluble Aβ oligomers through different cell surface receptors, including CD36 and TLRs, such as TLR2, TLR4, TLR6, and TLR9. The recognition by these receptors contributes to the activation of NF-κB, and consequent microglial activation and release of proinflammatory mediators, such as NO, IL-6, and IL-1β [ 3 , 4 ]. Also shown in studies with models of neuroinflammation using LPS, IL-1β, or Aβ oligomers is the effect of agathisflavone and other flavonoids in negatively regulating the expression of NF-κB and, consequently, of the inflammatory cytokines IL-6, IL-1β, TNF, and NOS2, contributing to the reduction of neuroinflammation [ 3 , 24 , 25 , 26 ].…”