Abstract:Hypothalamus is a major regulatory center in the brain responsible for various homeostasis processes. Distinct neurons and glial cells, including microglia support the cardiovascular functions in the hypothalamus. An important cardiovascular regulatory nucleus in the hypothalamus is the Paraventricular Nucleus (PVN). Previous studies from our laboratory showed evidence for cellular senescence in the PVN. Senescence is a state of irreversible growth arrest in proliferating cells, which has been implicated in se… Show more
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