Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1

Zhang, Dianquan; Cai, Guoliang; Li, Kai; Zhuang, Zhe; Jia, Kunping; Pei, Siying; Wang, Xiuzhen; Wang, Hong; Xu, Shengnan; Cui, Cheng; Sun, Manchao; Guo, Sihui; Song, Wenli; Cai, Guofeng

doi:10.18632/aging.202373

Cited by 61 publications

(38 citation statements)

References 77 publications

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“…MiRNAs are small noncoding RNAs (18-23 bp) that inhibit the translation of target mRNAs by interacting with the 3′-UTR (Tiwari et al, 2018;Chang et al, 2020;Sun et al, 2021;Zhang et al, 2021). On the basis of bioinformatics data, MT2 was predicted to be one of the genes targeted by miR-491-5p.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury

Tang

Guo²,

Chai³

et al. 2022

Neural Regen Res

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Section: Discussionmentioning

confidence: 99%

Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury

Tang

Guo²,

Chai³

et al. 2022

Neural Regen Res

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“…In vivo , Ex-miR-133b+ treatment significantly increased the functional improvement of ischemic border areas and neurite remodeling/brain plasticity ( 87 ). The exosomal miR-137 of microglia reduced infarct volume and behavioral defects in ischemic mice ( 88 ). Exosomal miR-138-5p derived from bone marrow stromal cells (BMSCs) alleviated neural lesions by promoting the proliferation of astrocytes, inhibiting apoptosis, and regulating inflammatory factors by downregulating LCN2 ( 89 ).…”

Section: Exosomal Mirnas As Therapeutic Agents In the Treatment Of St...mentioning

confidence: 99%

Exosomal microRNAs as Potential Biomarkers and Therapeutic Agents for Acute Ischemic Stroke: New Expectations

et al. 2022

Front. Neurol.

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The morbidity and mortality rates of ischemic stroke (IS) are very high, and IS constitutes one of the main causes of disability and death worldwide. The pathogenesis of ischemic stroke includes excitotoxicity, calcium overload, oxygen radical injury, inflammatory reactions, necrosis/apoptosis, destruction of the blood-brain barrier (BBB), and other pathologic processes. Recent studies have shown that exosomes are critical to the pathogenesis, diagnosis, and treatment of cerebral infarctions resulting from ischemic stroke; and there is growing interest in the role of exosomes and exosomal miRNAs in the diagnosis and treatment of IS. Exosomes from central nervous system cells can be found in cerebrospinal fluid and peripheral bodily fluids, and exosomal contents have been reported to change with disease occurrence. Exosomes are small membranous extracellular vesicles (EVs), 30–150 nm in diameter, that are released from the cell membrane into the depressions that arise from the membranes of multivesicular bodies. Exosomes carry lipids, proteins, mRNAs, and microRNAs (miRNAs) and transport information to target cells. This exosomal transfer of functional mRNAs/miRNAs and proteins ultimately affects transcription and translation within recipient cells. Exosomes are EVs with a double-membrane structure that protects them from ribonucleases in the blood, allowing exosomal miRNAs to be more stable and to avoid degradation. New evidence shows that exosomes derived from neural cells, endothelial cells, and various stem cells create a fertile environment that supports the proliferation and growth of neural cells and endothelial cells, inhibits apoptosis and inflammatory responses, and promotes angiogenesis. In the present review, we discuss how circulating exosomes—and exosomal miRNAs in particular—may provide novel strategies for the early diagnosis and treatment of ischemic stroke via their potential as non-invasive biomarkers and drug carriers.

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“…Increasing studies have indicated that cell-derived exosomes could inhibit apoptosis and contribute to alleviating cerebral injury in ischemic models [ 83 , 92 ]. Exosomes from different cells demonstrated neuroprotective potential in ischemia-induced neuronal death [ 105 , 118 , 119 , 120 ]. MiR-134 was involved in modulating neuronal cell death following ischemia–reperfusion injury [ 121 ].…”

Section: Potential Therapeutic Effects Of Exosomes In Ischemic Strokementioning

confidence: 99%

Potential Role of Exosomes in Ischemic Stroke Treatment

Jiang

Chen

et al. 2022

Biomolecules

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Ischemic stroke is a life-threatening cerebral vascular disease and accounts for high disability and mortality worldwide. Currently, no efficient therapeutic strategies are available for promoting neurological recovery in clinical practice, except rehabilitation. The majority of neuroprotective drugs showed positive impact in pre-clinical studies but failed in clinical trials. Therefore, there is an urgent demand for new promising therapeutic approaches for ischemic stroke treatment. Emerging evidence suggests that exosomes mediate communication between cells in both physiological and pathological conditions. Exosomes have received extensive attention for therapy following a stroke, because of their unique characteristics, such as the ability to cross the blood brain–barrier, low immunogenicity, and low toxicity. An increasing number of studies have demonstrated positively neurorestorative effects of exosome-based therapy, which are largely mediated by the microRNA cargo. Herein, we review the current knowledge of exosomes, the relationships between exosomes and stroke, and the therapeutic effects of exosome-based treatments in neurovascular remodeling processes after stroke. Exosomes provide a viable and prospective treatment strategy for ischemic stroke patients.

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Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1

Cited by 61 publications

References 77 publications

Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury

Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury

Exosomal microRNAs as Potential Biomarkers and Therapeutic Agents for Acute Ischemic Stroke: New Expectations

Potential Role of Exosomes in Ischemic Stroke Treatment

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