Microgels Loaded with Gold Nanorods:  Photothermally Triggered Volume Transitions under Physiological Conditions

Das, Mallika; Sanson, Nicolas; Fava, Daniele; Kumacheva, Eugenia

doi:10.1021/la061596s

Cited by 236 publications

(237 citation statements)

References 22 publications

(29 reference statements)

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“…By incorporating gold nanorods into NIPAAm microgels, photo-induced heating of the gold nanorods provided enough heat to induce the phase transition of the microgel providing a possible photoinduced drug release [159]. With similar work on grafting NIPAAm onto gold nanoparticles being done by Pérez-Luna et al [160].…”

Section: Particlesmentioning

confidence: 99%

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Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Particlesmentioning

confidence: 99%

“…Das et al showed another approach to polymer nanoparticle composites [159]. By incorporating gold nanorods into NIPAAm microgels, photo-induced heating of the gold nanorods provided enough heat to induce the phase transition of the microgel providing a possible photoinduced drug release [159].…”

Section: Particlesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…The rate of reaction of the individual comonomers influences the final composition of the resulting polymer, according to the Mayo-Lewis equation [7]. The compositions used for the preparation of the polymers are extremely diverse; they include NIPA, the aforementioned initiators, comonomers like acrylic acid (AcA) [8], methacrylic acid and fumaric acid [9], acrylamide [10], maleic acid [11], hydroxyethyl methacrylate, N-vinylpyrrolidone [12] or N-tert-butyl acrylamide [13,14], as well as 4-pentenoic acid [15].…”

Section: Methodsmentioning

confidence: 99%

The Conductivity and pH Values of Dispersions of Nanospheres for Targeted Drug Delivery in the Course of Forced Equilibrium Dialysis

Musiał¹,

Pluta²,

Byrski³

et al. 2015

Adv Clin Exp Med

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Background. In the available literature, the problem of pH and conductivity in FED is evaluated separately, and limited mainly to the final purity of the synthesized polymer. In this study data from conductivity and pH measurements were evaluated in the context of the structure of the macromolecule. Objectives. The aim of the study was to evaluate the conductivity and pH of dispersions of nanospheres synthesized with the use of N-isopropyl acrylamide (NIPA) as the main monomer, N,N'-methylenebisacrylamide (MBA) as the cross-linker and acrylic acid (AcA) as the anionic comonomer during the purification of dispersions via forced equilibrium dialysis (FED). Material and Methods. Six batches of nanospheres were obtained in the process of surfactant free precipitation polymerization (SFPP) under inert nitrogen. The conductivity and pH of the dispersions of nanospheres were measured at the beginning of FED and after finishing that process. The conductivity in the systems being studied decreased significantly in the process of FED. The initial values of conductivity ranged from 736.85 ± 8.13 μS × cm -1 to 1048.90 ± 67.53 μS × cm -1 After 10 days, when the systems being assessed gained stability in terms of conductivity level, the values of conductivity were between 4.29 ± 0.01 μS × cm -1 and 33.56 ± 0.04 μS × cm -1 . The pH values inreased significantly after FED. The resulting pH was between 6.92 ± 0.07 and 8.21 ± 0.07, while the initial values were between 3.42 ± 0.23 μS × cm -1 and 4.30 ± 0.22 μS × cm -1 . Conclusions. Conductivity and pH measurements performed during purification via FED provide important information on the composition of the resulting nanospheres, including the functional groups embedded in the structure of the polymer in the course of the synthesis, as well as the purity of the structures. The presence of a cross-linker and acidic comonomer in the poly-N-isopropyl acrylamide (polyNIPA) macromolecule may be confirmed by both the pH and the conductivity measurements (Adv Clin Exp Med 2015, 24, 2, 219-226).

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“…Nanocarriers typically target proteins, peptides, nucleic acids, DNA, and RNA [71,241,[248][249][250][251][252][253]. Polymeric structures and liposomes are usually employed as carriers, however, as stated above; polymers are large and cytotoxic and liposomes prone to leakage [254][255][256].…”

Section: Photothermal Transfectionmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Microgels Loaded with Gold Nanorods: Photothermally Triggered Volume Transitions under Physiological Conditions

Cited by 236 publications

References 22 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

The Conductivity and pH Values of Dispersions of Nanospheres for Targeted Drug Delivery in the Course of Forced Equilibrium Dialysis

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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