Microfragmented Adipose Tissue (M-FATS) for Improved Healing of Surgically Repaired Achilles Tendon Tears: A Preliminary Study

Ferracini, Riccardo; Artiaco, Stefano; Daghino, Walter; Falco, Mara; Garibaldi, Riccardo; Tiraboschi, Emilia; Guidotti, Claudio; Bistolfi, Alessandro

doi:10.1177/1938640020974557

Cited by 2 publications

(2 citation statements)

References 58 publications

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“…In a collagenase-induced AT mice model, AD-MSCs facilitate neovasculogenesis, upregulate tendon repair, downregulate ectopic ossification, and inhibit inflammation in Achilles tendon healing [ 99 ]. At 3 months follow-up, the improvement of AOFAS and FADI scores was observed in surgically managed Achilles tendon tears with micro fragmented adipose tissue (M-FAT) [ 100 ]. M-FAT downregulates the expression of type 3 collagen and metalloproteases-1 in a significant manner and upregulates the production of VEGF, IL-1Ra, and IL-6 in an in vitro model of tendinosis [ 101 ].…”

Section: Orthobiologics In Atmentioning

confidence: 99%

Application of Orthobiologics in Achilles Tendinopathy: A Review

Ramires

Jeyaraman

Muthu

et al. 2022

Life

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Orthobiologics are biological materials that are intended for the regeneration of bone, cartilage, and soft tissues. In this review, we discuss the application of orthobiologics in Achilles tendinopathy, more specifically. We explain the concepts and definitions of each orthobiologic and the literature regarding its use in tendon disorders. The biological potential of these materials can be harnessed and administered into injured tissues, particularly in areas where standard healing is disrupted, a typical feature of Achilles tendinopathy. These products contain a wide variety of cell populations, cytokines, and growth factors, which have been shown to modulate many other cells at local and distal sites in the body. Collectively, they can shift the state of escalated inflammation and degeneration to reestablish tissue homeostasis. The typical features of Achilles tendinopathy are failed healing responses, persistent inflammation, and predominant catabolic reactions. Therefore, the application of orthobiologic tools represents a viable solution, considering their demonstrated efficacy, safety, and relatively easy manipulation. Perhaps a synergistic approach regarding the combination of these orthobiologics may promote more significant clinical outcomes rather than individual application. Although numerous optimistic results have been registered in the literature, additional studies and clinical trials are still highly desired to further illuminate the clinical utility and efficacy of these therapeutic strategies in the management of tendinopathies.

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Section: Orthobiologics In Atmentioning

confidence: 99%

Application of Orthobiologics in Achilles Tendinopathy: A Review

Ramires

Jeyaraman

Muthu

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…They reported improvement in patient-reported outcomes, but follow-up was limited and there was no control group. 10 Ferracini et al 8 performed a small case-control study on Achilles tendon repair augmented with MFAT. Eight patients had their Achilles repair augmented with MFAT and were compared with nonaugmented repair.…”

Section: Video Transcriptmentioning

confidence: 99%

Lipoaspiration and Processing to Create Microfragmented Adipose Tissue

McGee

Baria

Gatewood

et al. 2022

Video Journal of Sports Medicine

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Background: Orthobiologics are increasingly used to treat musculoskeletal (MSK) conditions. Adipose may be a useful source of autologous cells for orthobiologic interventions. The lipoaspiration and processing techniques necessary to obtain these cells are not traditionally taught in most orthopedic training programs. Therefore, the goal of this video is to review the technique for adipose harvest and preparation to create microfragmented adipose tissue (MFAT). Indications: Currently, all MFAT applications are off-label. In practice, this is most commonly used for osteoarthritis and tendon disease. Technique Description: After local anesthesia is administered, a 17-gauge trochar is inserted into the subcutaneous adipose, and tumescent solution is injected. After a 5-minute waiting period, a separate 17-gauge harvest trochar is attached to the Autopose double-syringe (Arthrex; Naples, Florida) and is inserted into the subcutaneous adipose. Lipoaspiration is performed by moving the harvest device back and forth in a fan-like pattern. After 20 mL of lipoaspirate has been harvested from the first site, the lipoaspiration process is repeated on the contralateral side. After 40 mL of lipoaspirate has been harvested, the device is removed and decanted for 3 to 5 minutes. Then, 10 mL of sterile saline solution is injected into the device using the Luer lock attachment. This rinse process is repeated a second time. Once the excess fluid has been removed, the device is capped, and the outer syringe is slowly pushed down to move the tissue through the resizing filter. The inner syringe is removed and contains the final MFAT product. Discussion/Conclusion: Lipoaspirate is a simple technique that can be performed in the clinic or operating room to create MFAT. This provides a unique population of autologous cells that may be beneficial for treating MSK pathology.

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Microfragmented Adipose Tissue (M-FATS) for Improved Healing of Surgically Repaired Achilles Tendon Tears: A Preliminary Study

Cited by 2 publications

References 58 publications

Application of Orthobiologics in Achilles Tendinopathy: A Review

Application of Orthobiologics in Achilles Tendinopathy: A Review

Lipoaspiration and Processing to Create Microfragmented Adipose Tissue

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