Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians

Abstract

Angiogenesis, the formation of new blood vessels, has received much research attention due to its implications in physiological processes and diseases. Most studies using traditional in vitro and in vivo...

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

“…3.2 | Organ-on-a-chip models of the vasculature OOC approaches to engineer the vasculature have been recently reviewed in the literature, 37,136 including progress on atherosclerosis models. 137 Therefore, this review will instead discuss which features of the vasculature are present in the current research and what are the shortcomings as of now.…”

Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications

“…Since the 21st century, microfluidics has been widely used in mechanical engineering, biomedical engineering, materials engineering, and other fields, such as organ mimic devices, high-throughput screening, and the preparation of new biological materials [57][58][59]. Therefore, microfluidic devices play a significant role in CVDs research.…”

Dynamic investigation of zein-based degradable and hemocompatible coatings for drug-eluting stents: a microfluidic approach

“…With their versatile features, including small sample volume and adaptable flow conditions, lab-on-a-chip platforms offer the desirable option for conducting in vitro tests in a dynamic environment, recapitulating the physiological one more faithfully than experiments in conventional static cell culture dishes. 11 Moreover, microfluidic systems allow the sinking conditions around the material to be easily maintained by imposing a continuous flow inside the channels so that the released molecules can be easily dispersed into the flowing medium instead of accumulating, as in the case of a static setting, thus avoiding the effect of early leveling of the concentration gradient on elution kinetics. 12 So far, microfluidic chambers for biomedical applications have been mostly fabricated with soft polymeric materials, in particular with the low-cost and biocompatible polydimethylsiloxane (PDMS), which can be handled to assemble user-defined shaped flow channels.…”

“…18 Regarding hemocompatibility studies, microfluidic platforms have been only recently investigated as potential instruments for evaluating dynamic biological interactions of desired drugs and compounds. 11,19 However, previous studies have almost exclusively focused on platelet adhesion and activation mechanisms on selected molecules, such as tissue factors and anti-thrombotic drugs, using both custom-made and commercial flow devices, as described by Provenzale et al 20 Herein, we report the design, fabrication, and validation of novel fused silica-based microfluidic platforms for investigating the hemocompatibility and dynamic behavior of drug-eluting materials for stent applications. In our previous study, we developed biodegradable DES coatings by exclusively employing biocompatible naturally-derived materials and compounds.…”

“…18 Regarding hemocompatibility studies, microfluidic platforms have been only recently investigated as potential instruments for evaluating dynamic biological interactions of desired drugs and compounds. 11,19 However, previous studies have almost exclusively focused on platelet adhesion and activation mechanisms on selected molecules, such as tissue factors and anti-thrombotic drugs, using both custom-made and commercial flow devices, as described by Provenzale et al 20…”