Microfluidics for diagnosis and treatment of cardiovascular disease

Ma, Yonggeng; Liu, Chenbin; Cao, Siyu; Chen, Tianshu; Chen, Guifang

doi:10.1039/d2tb02287g

Cited by 13 publications

(13 citation statements)

References 94 publications

(103 reference statements)

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“…[116][117][118] This provides scientists with a reliable solution to explore cardiovascular-related diseases in vitro from pathogenesis to disease treatment based on the possibility of successfully constructing microfluidicbased cardiac pathology chips and vascular pathology chip models. 119,120 In this vein, the blood vessel-on-achip that can simulate blood perfusion and cell-cell interactions has been designed to study the pathogenesis of vascular diseases through in vitro microvasculature. 121 Sano and colleagues designed a microvascular microchip model and co-cultured mesenchymal stem cells (MSCs), including capillary-resident stem cells (CapSCs) and adipose-derived stromal cells (ASCs), and HUVECs in this microvessel-on-a-chip.…”

Section: Investigating the Development Of Cardiovascular Disease Usin...mentioning

confidence: 99%

“…Microfluidics has shown great advantages in simulating the biometric microenvironment, such as blood vessels and tissue interstices, by precisely controlling the flow and mixing of fluids, which can be used in the development and progression of CVD models accurately 116–118 . This provides scientists with a reliable solution to explore cardiovascular‐related diseases in vitro from pathogenesis to disease treatment based on the possibility of successfully constructing microfluidic‐based cardiac pathology chips and vascular pathology chip models 119,120 . In this vein, the blood vessel‐on‐a‐chip that can simulate blood perfusion and cell‐cell interactions has been designed to study the pathogenesis of vascular diseases through in vitro microvasculature 121 .…”

Section: Application Of Ooc In Cardiovascular Disease Researchmentioning

confidence: 99%

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Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases

Liu,

Wang

2023

MedComm – Biomaterials and Applications

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Cardiovascular disease (CVD) is currently a serious and growing public health problem. In tackling this challenge, organ‐on‐chip (OoC) technology, combined with cell culture and microfluidics, presents a powerful approach for constructing sophisticated tissue models in vitro that can simulate the physiological and pathological microenvironments of human organs. Nowadays, OoC technology has emerged as a pivotal tool in advancing our understanding of CVD pathogenesis, facilitating tissue regeneration studies, conducting efficient drug screening, and assessing therapeutic effects. Moreover, it offers a diverse array of study platforms for preclinical research, fostering innovative approaches towards combating CVD and improving patient outcomes. In this review, we first present the key advantages of OoC technology, including its highly relevant physiological microenvironment, incorporation of integrated functions, and the possibility of the construction of multiorgan‐on‐a‐chip through microfluidic linkage. Then, we summarized the role of OoC in the construction of disease pathological models, which provides a new channel for the exploration of disease pathological mechanisms. Moreover, we discuss the application of this technology in cardiac regeneration and drug screening. Finally, we discuss the challenges of tissue models constructed based on OoC technology and the prospects of this innovative approach.

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Section: Investigating the Development Of Cardiovascular Disease Usin...mentioning

confidence: 99%

Section: Application Of Ooc In Cardiovascular Disease Researchmentioning

confidence: 99%

Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases

Liu,

Wang

2023

MedComm – Biomaterials and Applications

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“…Microfluidics is an interdisciplinary field that involves the manipulation of small volumes of fluids, typically in the microliter to picoliter range. It has evolved from the miniaturization of chemical processes in the 1970s to the development of “lab-on-a-chip” technology and the preceding concept of micro total analysis systems (µ-TAS) in the 1990s [ 1 ], enabling nowadays complete analytical laboratories on a single microchip [ 2 , 3 , 4 , 5 , 6 ]. Well beyond the drastic reduction of sample volume, reagent consumption, and waste, this miniaturization provides important advantages for the improvement of the analytical performance, such as an increase of sensitivity, a reduction of analysis time, and the possibility of multiple parallelization without an increase of system complexity and environmental footprint.…”

Section: Introductionmentioning

confidence: 99%

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

Kurdadze,

Lamadie,

Nehme

et al. 2024

Sensors

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Microfluidics has emerged as a robust technology for diverse applications, ranging from bio-medical diagnostics to chemical analysis. Among the different characterization techniques that can be used to analyze samples at the microfluidic scale, the coupling of photonic detection techniques and on-chip configurations is particularly advantageous due to its non-invasive nature, which permits sensitive, real-time, high throughput, and rapid analyses, taking advantage of the microfluidic special environments and reduced sample volumes. Putting a special emphasis on integrated detection schemes, this review article explores the most relevant advances in the on-chip implementation of UV–vis, near-infrared, terahertz, and X-ray-based techniques for different characterizations, ranging from punctual spectroscopic or scattering-based measurements to different types of mapping/imaging. The principles of the techniques and their interest are discussed through their application to different systems.

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“…Electrocardiograms and cardiac magnetic resonance (CMR) are often the gold standard for diagnosing certain cardiovascular diseases, but the application of these assistive tools are limited by high cost, high requirements for technical expertise, and is not suitable as a screening tool for the general population. 3 , 4 This brings a lot of difficulties to early diagnosis of CVD and seriously affects the recovery of patients. In order to break through the current bottleneck, emerging technologies such as immunochromatography and microfluidic technology have the advantages of low cost, simple instruments, and easy integration, and have been developed to a relatively mature level.…”

Section: Introductionmentioning

confidence: 99%

“…In order to break through the current bottleneck, emerging technologies such as immunochromatography and microfluidic technology have the advantages of low cost, simple instruments, and easy integration, and have been developed to a relatively mature level. 4 They play an important role in the early prevention, diagnosis, and treatment of cardiovascular diseases. However, considering the application situation, microfluidic technology still has certain limitations.…”

Section: Introductionmentioning

confidence: 99%

A One Step Strategy Based on Hollow Gold Nanoparticles to Detect C-Reactive Protein with High Sensitivity (Hs-CRP) in Serum for Monitoring Cardiovascular Disease

Luo,

Zhang,

Liu

et al. 2024

IJN

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Purpose Rapid detection and diagnosis of diseases facilitate timely and effective treatment of cardiovascular diseases (CVD). The establishment of a one-step rapid detection method provides a new method for the initial screening and disease risk assessment of patients with cardiovascular diseases in primary medical units. Methods Hollow gold nanoparticles (HGNPs) were synthesized using a cobalt template method followed by use as signal amplification probes for ultra-sensitive quantitative detection of serum C-reactive protein (CRP). To induce the localized surface plasmon resonance (LSPR) and improve protein labeling efficiency, we developed a sensitive detection mode by coating polyvinylpyrrolidone (PVP-K30) on the HGNPs, resulting in a significant improvement in detection performance. Results Compared to traditional colloidal GNP-based LFTA, PVP-coated HGNPs exhibit a lower visual detection limit of 1 ng/mL, which a 25-fold decrement compare to using GNPs as the antibody-labeled probe, and the detection limit could be reduced to 0.14 ng/mL under the quantitative instrument. Conclusion The one-step method based on HGNP immunochromatographic strips modified with PVP established in this study can be used for the detection of CRP and hs-CRP in biological samples. The performance of the immunochromatographic technique designed in this study was evaluated from the perspective of synthetic markers, and the application conditions of this strip were screened, verifying its high specificity, indicating that it has high sensitivity and strong detection limit compared to colloidal gold. The sensitivity of the hollow gold immunochromatographic test strip in this article has been increased by about 25 times, providing a new method for rapid detection of CVD in clinical diagnosis.

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Microfluidics for diagnosis and treatment of cardiovascular disease

Abstract: Cardiovascular disease (CVD), a type of circulatory system disease related to the lesions of the cardiovascular system, has become one of the main diseases that endanger human health. Currently, the...

Cited by 13 publications

References 94 publications

Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases

Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

A One Step Strategy Based on Hollow Gold Nanoparticles to Detect C-Reactive Protein with High Sensitivity (Hs-CRP) in Serum for Monitoring Cardiovascular Disease

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