Microfluidics for Angiogenesis Research

Mechanobiological approaches to synthetic morphogenesis: learning by building

“…Synthetic systems investigating branching processes typically have a fixed network topology (rev. in [87]). However, some use MMP-degradable substrates, natural or synthetic [88] ones, to investigate network remodeling.…”

Electroosmotic Micromixing in Physicochemically Patterned Microchannels

“…It is now well-known that there are multifold advantages of using microfluidic devices over macroscopic ones owing to their portability, ease of use, availability of a higher surface-to-volume ratio for the process intensified engineering processes, control over the reagent parameters owing to their usage of smaller volumes, and capacity to bring in the aspects of very-large-scale integration (VLSI) for a larger throughput and multitasking, among others. Thus, such microfluidic platforms are found to appear in diverse modern-day functionalities that include drug delivery, − point-of-care diagnostics, − tissue engineering, − high-throughput screening, − protein crystallization, − and deoxyribonucleic acid (DNA) analysis. , In particular, the success in the integration of multiplexing of microfluidic devices on the lab-on-a-chip , platforms has led to the development of portable laboratory prototypes in the diverse areas of biology, − chemistry, − medicine, , and engineering. , However, several limitations related to microfluidic platforms have emerged over the years, including the diffusion-limited mixing capacity, a relatively lower throughput, and crowding–clogging of transport materials, among others. Of late, such areas have become intense scientific and engineering research.…”

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

“…These results primarily highlight the use of more than one type of cells cocultured, as a miniature for a particular human organ-tissue, simple functional assays and specific characterization of tissue-tissue/cell-cell communications ( Ahmed, 2022 ). These research assessed the current breakthroughs in organ on chip platform, recognized new limitations that must be conquered to reorganize organ on chip platform models into respectable human Pathophysiologically relevant models, and discussed potential avenues of research to pursue in this area in the future ( Costa et al, 2020 ; Ramadan and Zourob, 2020 ). According to Skardal et al remarkable improvement has been accomplished in the design and use of complex multi-organ on chip platform and body on a chip, in addition to the implementation of this organ on chip platform technology for drug efficacy and toxicity testing, personalized medicine and disease modeling ( Figure 1A ) ( Skardal et al, 2016 ).…”