Microfluidics: Applications for analytical purposes in chemistry and biochemistry

Ohno, Kenichi; Tachikawa, Kaoru; Manz, Andreas

doi:10.1002/elps.200800121

Cited by 350 publications

(202 citation statements)

References 132 publications

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“…Craighead (2006) focused upon the application of microfluidics in an integrated, lab-on-a-chip approach to find and characterize individual biomolecules of particular importance to the future of acoustic microfluidics in Sec. V. Ohno et al (2008) presented a review of microfluidics as applied to analytical chemistry and biochemistry, and Salieb-Beugelaar et al (2010) provided a recent review of microfluidics applied to cellular biology, both from the same group that established microfluidics thinking in this same area some 10 years prior; Meyvantsson and Beebe (2008) provided a thorough review on the application of microfluidics to cell culture. Ho et al (2011) provided a comprehensive and broad review of laboratory and consumer biotechnological applications emerging from the past decade of microfluidics.…”

Section: Microfluidicsmentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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This article reviews acoustic microfluidics: the use of acoustic fields, principally ultrasonics, for application in microfluidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

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Section: Microfluidicsmentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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“…The last decade has witnessed an explosive growth in applications of microfluidic channels to chemical and biological fields [1][2][3][4][5]. This has been driven by the trends of shrinking conventional benches to a small size to realize major advantages of efficiency, performance, integration, speed and cost.…”

Section: Introductionmentioning

confidence: 99%

Effect of Laser-Induced Heating on Raman Measurement within a Silicon Microfluidic Channel

Lin

Wang

et al. 2015

Micromachines

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When Raman microscopy is adopted to detect the chemical and biological processes in the silicon microfluidic channel, the laser-induced heating effect will cause a temperature rise in the sample liquid. This undesired temperature rise will mislead the Raman measurement during the temperature-influencing processes. In this paper, computational fluid dynamics simulations were conducted to evaluate the maximum local temperature-rise (MLT). Through the orthogonal analysis, the sensitivity of potential influencing parameters to the MLT was determined. In addition, it was found from transient simulations that it is reasonable to assume the actual measurement to be steady-state. Simulation results were qualitatively validated by experimental data from the Raman measurement of diffusion, a temperature-dependent process. A correlation was proposed for the first time to estimate the MLT. Simple in form and convenient for calculation, this correlation can be efficiently applied to Raman measurement in a silicon microfluidic channel.

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“…Microfluidics research and development has emerged as a novel and promising tool for the development of applications as varied as cell sorting, 1, 2 chemical and biochemical analysis, 3 drug discovery, 4 chemical reactors, 5 and others. 6,7 These applications have been coupled with the parallel development of appropriate liquid handling tools such as micropumps 8 and valves 9 as well as the study of the fluid mechanics of such devices.…”

Section: Introductionmentioning

confidence: 99%

Transport of airborne particles in straight and curved microchannels

2012

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The measurement of airborne particles is important for environmental and exposure monitoring. Microfluidic technologies present potential advantages for aerosol monitoring but have been applied very little to the handling of airborne particles. In this paper, we examine the flow focusing and cross-streamline diffusion of aerosols in straight microchannels, and the size-based lateral displacement of aerosols caused by centrifugal forces in a curved channel. We present calculations, simulations, and experimental results verifying the models: measurements of the focusing and diffusion of 0.2 μm and 0.75 μm particles in straight channels and of the size-dependent lateral displacement of particles between 0.2 μm and 2 μm in curved channels are demonstrated and shown to match well with the simulations. We observe lateral dispersion of the particles: particles closer to the top and bottom wall of the channel experience less lateral displacement than particles near the center due to the flow velocity distribution across the channel cross section. These results confirm that the microchannel techniques presented are a viable method for the size-based manipulation of airborne particles.

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Microfluidics: Applications for analytical purposes in chemistry and biochemistry

Cited by 350 publications

References 132 publications

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Effect of Laser-Induced Heating on Raman Measurement within a Silicon Microfluidic Channel

Transport of airborne particles in straight and curved microchannels

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