Microfluidic wound scratching platform based on an untethered microrobot with magnetic actuation

Cell Migration Assays and Their Application to Wound Healing Assays—A Critical Review

“…It is worth mentioning that the geometry of CFZs in the existing CMA is a two-dimensional area, which does not represent the complexity of the real situation of the wound, which says that the depth of the wound matters in vivo. In a pilot study by [ 32 ], a robotic device was developed to create CFZs at different geometric shapes including line, crosshead, rectangle, and triangle shapes (see Figure 2 in Section 2.1.1 ). However, this device has limitations.…”

“…Second, the device has a limitation in the shear stress condition. In the study of [ 32 ], the mechanical force on the cells was created by magnetic force. The magnetic force can be decomposed into the vertical force to apply pressure on cells, and horizontal force to drag the device moving (see Figure 2 ).…”

“…According to Yilmaz et al, the consistency of the CFZs can reach 2% [32]. Their study also suggested that wounds with more edges of CFZs may have a faster healing time.…”

“…Yilmaz et al developed a scratch robot enabling us to create CFZs with different shapes and geometries of CFZs (see in Figure 2 a) [ 32 ]. The robot is based on magnetic actuation (see in Figure 2 b), enabling us to create CFZs of different shapes of wounds (see in Figure 2 c) such as line wound, ‘plus’ shape wound, rectangle wound, and triangle wound.…”

“…The robot is based on magnetic actuation (see in Figure 2 b), enabling us to create CFZs of different shapes of wounds (see in Figure 2 c) such as line wound, ‘plus’ shape wound, rectangle wound, and triangle wound. According to Yilmaz et al, the consistency of the CFZs can reach 2% [ 32 ]. Their study also suggested that wounds with more edges of CFZs may have a faster healing time.…”