Microfluidic traps for hard-wired operations on droplets

Korczyk, Piotr M.; Derzsi, Ladislav; Jakieła, Sławomir; Garstecki, Piotr

doi:10.1039/c3lc50347j

Cited by 55 publications

(66 citation statements)

References 33 publications

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“…Another great example of passive channel geometries has been shown by Korczyk et al, only by changing the flows their channel geometries are able to precisely meter a volume from a larger drop, merge droplets to create droplets of different concentration, delay a droplet and have a droplet shift register [30].…”

Section: Geometric Structuresmentioning

confidence: 99%

Droplet Manipulations in Two Phase Flow Microfluidics

2015

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Even though droplet microfluidics has been developed since the early 1980s, the number of applications that have resulted in commercial products is still relatively small. This is partly due to an ongoing maturation and integration of existing methods, but possibly also because of the emergence of new techniques, whose potential has not been fully realized. This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics. Specifically, very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed. The physical principles are explained, and (potential) advantages and drawbacks of different methods in the sense of versatility, flexibility, tunability and durability are discussed, where possible, per technique and per droplet operation: generation, transport, sorting, coalescence and splitting.

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Section: Geometric Structuresmentioning

confidence: 99%

Droplet Manipulations in Two Phase Flow Microfluidics

2015

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“…12 Several types of geometry have been reported, 13 and the design and test routine is time and effort consuming when debugging new designs. Here, we focussed on showing the ability of the video-projector technology to produce masks that will enable researchers to fabricate "on demand" droplet generation devices.…”

Section: Microfluidic Chip For Droplet Generationmentioning

confidence: 99%

Rapid mask prototyping for microfluidics

et al. 2016

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With the rise of microfluidics for the past decade, there has come an ever more pressing need for a low-cost and rapid prototyping technology, especially for research and education purposes. In this article, we report a rapid prototyping process of chromed masks for various microfluidic applications. The process takes place out of a clean room, uses a commercially available video-projector, and can be completed in less than half an hour. We quantify the ranges of fields of view and of resolutions accessible through this video-projection system and report the fabrication of critical microfluidic components (junctions, straight channels, and curved channels). To exemplify the process, three common devices are produced using this method: a droplet generation device, a gradient generation device, and a neuro-engineering oriented device. The neuro-engineering oriented device is a compartmentalized microfluidic chip, and therefore, required the production and the precise alignment of two different masks.

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“…Existing approaches have been able to capture single droplets [13][14][15][16][17][18][19]29 and cells 30 but the selection of individual droplets/particles in these studies is random. In contrast, the controlled trapping of individual droplets has been shown using small groves in the channel but the system involves only a very small flow or droplet rate 10,31 (e.g. 10 µl h −1 for the dispersed phase resulting in about 30 drops per s).…”

Section: Introductionmentioning

confidence: 99%

“…8,9 The metering, splitting, merging and moderating of the speed of a single droplet has been impressively demonstrated. [10][11][12] Yet, most of the microfluidic devices developed have focussed on the analysis of droplets in arrays (i.e. in batches), [13][14][15][16][17][18][19][20][21][22] while others operate on single drops one by one in series.…”

Section: Introductionmentioning

confidence: 99%

Fast selective trapping and release of picoliter droplets in a 3D microfluidic PDMS multi-trap system with bubbles

Rambach

Biswas

Yadav

et al. 2018

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The selective manipulation and incubation of individual picoliter drops in high-throughput droplet based microfluidic devices still remains challenging. We used a surface acoustic wave (SAW) to induce a bubble in a 3D designed multi-trap polydimethylsiloxane (PDMS) device to manipulate multiple droplets and demonstrate the selection, incubation and on-demand release of aqueous droplets from a continuous oil flow. By controlling the position of the acoustic actuation, individual droplets are addressed and selectively released from a droplet stream of 460 drops per s. A complete trapping and releasing cycle can be as short as 70 ms and has no upper limit for incubation time. We characterize the fluidic function of the hybrid device in terms of electric power, pulse duration and acoustic path.

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Microfluidic traps for hard-wired operations on droplets

Cited by 55 publications

References 33 publications

Droplet Manipulations in Two Phase Flow Microfluidics

Droplet Manipulations in Two Phase Flow Microfluidics

Rapid mask prototyping for microfluidics

Fast selective trapping and release of picoliter droplets in a 3D microfluidic PDMS multi-trap system with bubbles

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