“…The mixing of multiple reagents was isolated in the liquid slugs by introducing the immiscible carrier phase in the winding microchannels, and the chaotic advection appeared in slugs by internal circulations, which could stretch and fold the fluids striation, eventually the intensification of the mixing in droplets could be obtained (Bringer et al, 2004). Reactions in slugs in microchannels have attracted many researchers due to the elimination of Taylor dispersion and the enhanced mixing performance by internal circulation, such as measurement of fast reaction kinetics parameters (Song and Ismagilov, 2003), protein crystallization (Zheng et al, 2004), synthesis of nanoparticles (Khan and Jensen, 2007), etc. Nevertheless, the multiphase flow approach involve the separation of the gas-liquid two phases or the liquid-liquid two phases after the outlet of the microchannel.…”