Microfluidic Synthesis of Nanomaterials

Song, Yujun; Hormes, J.; Kumar, Challa S. S. R.

doi:10.1002/smll.200701029

Cited by 428 publications

(345 citation statements)

References 108 publications

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“…[196] This in situ monitoring of chemical reactions comes in handy for time-resolved analysis or mechanistic studies. [42] c. New concepts production:…”

Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning

confidence: 99%

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Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…[196] This in situ monitoring of chemical reactions comes in handy for time-resolved analysis or mechanistic studies. [42] c. New concepts production:…”

Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning

confidence: 99%

“…[50,196] Table 3 compares these two microfluidic strategies by their advantages and disadvantages. This section will summarize these two approaches with focus on introducing some basic concepts and their applications in the synthesis of MNPs.…”

Section: Microfluidic Strategies For Synthesizing Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

View full text Add to dashboard Cite

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“…(NAKAMURA et al, 2004;YANG et al, 2009;MARRE e JENSEN, 2010;LIU et al, 2014;LIN et al, 2015;WATT et al, 2015;MA et al, 2017;SWAIN et al, 2017) A microfluídica é utilizada para obter nanopartículas com maior monodispersão em comparação a métodos tradicionais, que requerem etapas posteriores de purificação para este fim. (SONG et al, 2008;HARTMAN e JENSEN, 2009;YANG et al, 2009)(DITTRICH, 2005MA et al, 2017 segundos, produzindo alta eficiência quântica (35-55%) e mantendo uma faixa de FWHM estreita (26 -31 nm), importante para uma distribuição monodispersa.…”

Section: Síntese De Quantum Dots Em Fluxounclassified

“…Na Tabela 1 pode-se observar a variedade de formas e métodos para síntese de nanopartículas metálicas em plataformas microfluídicas para facilitar a comparação entre os seus tipos, tamanho, forma e o substrato da plataforma microfluídica. (SONG et al, 2008;ZHANG e NOGUEZ, 2008;MA et al, 2017 …”

Section: Síntese De Nanopartículas Metálicas Em Fluxounclassified