Microfluidic synthesis of multilayered lipid–polymer hybrid nanoparticles for the formulation of low solubility drugs

Abstract

Hybrid phospholipid/block copolymer membranes where polymers and lipids are molecularly mixed or phase-separated into polymer-rich and lipid-rich domains are promising drug delivery materials. Harnessing the chemical diversity of polymers and...

Cooperative Self-Assembly of Lipid–Polymer Hybrids Stabilizing Highly Ordered Bicontinuous Cubic Phases in Air

“…Lipid–BCP hybrid membranes have synergistic structural and functional properties otherwise not achievable with the assembly of single components. Previous studies reported advanced properties of the lipid–polymer co-assemblies, e.g., improved mechanical stability, − controllable solubility of encapsulated solutes in membranes, − synergistic permeability of cargo drugs, − and control of polymer crystallization and thermal properties. , Research on lipid–BCP hybrid membranes has been mainly conducted on lamellar systems in the form of vesicles dispersed in water, , monolayer suspended in water, or bilayers on solid supports, − leaving a gap in our understanding of polymorphism of the lipid–BCP hybrid system. Nonetheless, lipid–BCP mixtures hold a huge potential in creating nonlamellar structures with increasingly complex structures and topologies given that each amphiphile has the ability to self-assemble into various nanostructures.…”