Microfluidic synthesis of chiral salen Mn(ii) and Co(ii) complexes containing lysozyme

Abstract

Efficient microfluidic synthesis of chiral salen Mn(ii) and Co(ii) complexes containing lysozyme was achieved.

Synthesis of an azo-Mn(ii) complex with mild pH control using a microfluidic device

“…26 However, Tanaka et al have also described the synthesis of Mn(II) and Co(II) salen complexes using microuidic devices. 24 In this study, the reaction time was too short for the reagents to react with oxygen because they owed continuously into the microuidic device. However, in the conventional method, the reaction mixture was stirred, and metal acetate was oxidised.…”

“…Reagents and solutions were introduced by a syringe using a syringe pump. 24 2.3.2 Preliminary experimentssynthesis of the azo compound (step I). We conducted preliminary experiments to determine the appropriate concentration of the pH-adjustment reagent for the uidic experiments ( Table 1).…”

“…21,22 The synthesis of the metal complexes using the microuidic device required a shorter reaction time and no temperature or atmospheric control. 23,24 Furthermore, the conventional synthesis of azo compounds requires harsh pH adjustments using high concentrations of hydrochloric acid and sodium hydroxide. However, highly concentrated reagents lead to decomposition of the compounds (Fig.…”

“…According to previous studies, microuidic devices can permit a more than 10 000fold increase in the rates of chemical reactions. 23,24 We, therefore, focused on the high reactivity that could be achieved with a microuidic device. The device is likely to reduce the required concentration of pH-adjustment reagents.…”

Microdroplet synthesis of azo compounds with simple microfluidics-based pH control

“…The device was constructed from polydimethylsiloxane (PDMS) with a channel width and depth of 200 and 100 mm, respectively. 21 Solutions of the reagents were introduced via syringe using a syringe pump. Fig.…”