Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

Applegate, Robert W.; Squier, Jeff; Vestad, Tor; Oakey, John; Marr, David W. M.; Bado, Philippe; Dugan, Mark; Said, Ali A.

doi:10.1039/b512576f

Cited by 172 publications

(92 citation statements)

References 20 publications

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“…Applegate et al generated a linear trap with size 1 Â 100 mm by moderate focusing of a laser diode bar beam and tilted the long axis of this trap with respect to the fluid flow [348][349][350] (see Fig. 15).…”

Section: Active Sorting With Optical Forcesmentioning

confidence: 99%

Light at work: The use of optical forces for particle manipulation, sorting, and analysis

2008

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We review the combinations of optical micro-manipulation with other techniques and their classical and emerging applications to non-contact optical separation and sorting of micro- and nanoparticle suspensions, compositional and structural analysis of specimens, and quantification of force interactions at the microscopic scale. The review aims at inspiring researchers, especially those working outside the optical micro-manipulation field, to find new and interesting applications of these methods.

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Section: Active Sorting With Optical Forcesmentioning

confidence: 99%

Light at work: The use of optical forces for particle manipulation, sorting, and analysis

2008

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“…In this Section we present a fluorescence activated cell sorter (FACS) which allows to trap, detect and sort fluorescently labeled cells inside a microfluidic channel [103]. A first laser beam (the trapping beam) is used to trap cells inside the channel, while a second beam (the sensing beam) is used to excite their fluorescence and then to sort them into the desired channel by releasing, at a suitable time, the trapping beam.…”

Section: Cell Sortingmentioning

confidence: 99%

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Osellame

Hoekstra

Cerullo

et al. 2011

Laser & Photonics Reviews

286

226

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This paper provides an overview of the rather new field concerning the applications of femtosecond laser microstructuring of glass to optofluidics. Femtosecond lasers have recently emerged as a powerful microfabrication tool due to their unique characteristics. On the one hand, they enable to induce a permanent refractive index increase, in a micrometer-sized volume of the material, allowing single-step, three-dimensional fabrication of optical waveguides. On the other hand, femtosecond-laser irradiation of fused silica followed by chemical etching enables the manufacturing of directly buried microfluidic channels. This opens the intriguing possibility of using a single laser system for the fabrication and three-dimensional integration of optofluidic devices. This paper will review the state of the art of femtosecond laser fabrication of optical waveguides and microfluidic channels, as well as their integration for high sensitivity detection of biomolecules and for cell manipulation.

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“…Once trapped, individual, and multi-particle translations and manipulations have been achieved through the translation of the fluid, flowcell, or laser beam. [8][9][10] Successful separation of microscopic particles based on their appearance has also been achieved, 11 while more recent work has utilized arrays of optical traps to separate particles based upon their intrinsic optical mobilities. 8 Other techniques involve manipulating the incident laser beam to separate samples.…”

Section: Introductionmentioning

confidence: 99%

Optical chromatographic sample separation of hydrodynamically focused mixtures

Terray

Hart

2010

SPIE Proceedings

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Optical chromatography relies on the balance between the opposing optical and fluid drag forces acting on a particle. A typical configuration involves a loosely focused laser directly counter to the flow of particle-laden fluid passing through a microfluidic device. This equilibrium depends on the intrinsic properties of the particle, including size, shape, and refractive index. As such, uniquely fine separations are possible using this technique. Here, we demonstrate how matching the diameter of a microfluidic flow channel to that of the focusing laser in concert with a unique microfluidic platform can be used as a method to fractionate closely related particles in a mixed sample. This microfluidic network allows for a monodisperse sample of both polystyrene and poly(methyl methacrylate) spheres to be injected, hydrodynamically focused, and completely separated. To test the limit of separation, a mixed polystyrene sample containing two particles varying in diameter by less than 0.5 lm was run in the system. The analysis of the resulting separation sets the framework for continued work to perform ultra-fine separations.

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Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

Cited by 172 publications

References 20 publications

Light at work: The use of optical forces for particle manipulation, sorting, and analysis

Light at work: The use of optical forces for particle manipulation, sorting, and analysis

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Optical chromatographic sample separation of hydrodynamically focused mixtures

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