Microfluidic Rheometer for Characterization of Protein Unfolding and Aggregation in Microflows

Choi, Sungyoung; Park, Je‐Kyun

doi:10.1002/smll.201000210

Cited by 43 publications

(38 citation statements)

References 26 publications

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“…Like the flow speed, measuring pressure in microfluidic channels is important for many applications. [47][48][49] Pressure in a microchannel is usually measured with external pressure transducers and it's difficult to measure the local pressure accurately. Song et al introduced the technique of an optofluidic membrane interferometer that can measure the microfluidic pressure and flow rate simultaneously.…”

Section: Bulky Optical Imaging Techniquesmentioning

confidence: 99%

Optical imaging techniques in microfluidics and their applications

2012

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Microfluidic devices have undergone rapid development in recent years and provide a lab-on-a-chip solution for many biomedical and chemical applications. Optical imaging techniques are essential in microfluidics for observing and extracting information from biological or chemical samples. Traditionally, imaging in microfluidics is achieved by bench-top conventional microscopes or other bulky imaging systems. More recently, many novel compact microscopic techniques have been developed to provide a low-cost and portable solution. In this review, we provide an overview of optical imaging techniques used in microfluidics followed with their applications. We first discuss bulky imaging systems including microscopes and interferometer-based techniques, then we focus on compact imaging systems that can be better integrated with microfluidic devices, including digital inline holography and scanning-based imaging techniques. The applications in biomedicine or chemistry are also discussed along with the specific imaging techniques.

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Section: Bulky Optical Imaging Techniquesmentioning

confidence: 99%

Optical imaging techniques in microfluidics and their applications

2012

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“…Therefore, at a given pressure drop between channel ends, the flow rate through a microchannel only depends on the fluid viscosity and is linearly decreased as the fluid becomes more viscous. 5 From this relationship, we can calculate the viscosity of blood if the fluid viscosity and feeding rates through the reference channel and the test channel are known, as the following formula: 5…”

Section: -mentioning

confidence: 99%

Microfluidic parallel circuit for measurement of hydraulic resistance

2010

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We present a microfluidic parallel circuit that directly compares the test channel of an unknown hydraulic resistance with the reference channel with a known resistance, thereby measuring the unknown resistance without any measurement setup, such as standard pressure gauges. Many of microfluidic applications require the precise transport of fluid along a channel network with complex patterns. Therefore, it is important to accurately characterize and measure the hydraulic resistance of each channel segment, and determines whether the device principle works well. However, there is no fluidic device that includes features, such as the ability to diagnose microfluidic problems by measuring the hydraulic resistance of a microfluidic component in microscales. To address the above need, we demonstrate a simple strategy to measure an unknown hydraulic resistance, by characterizing the hydraulic resistance of microchannels with different widths and defining an equivalent linear channel of a microchannel with repeated patterns of a sudden contraction and expansion.

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“…Based on this idea, methods of measuring viscosity by image acquisition and processing of the cross-sectional area [20] or channel width [21] at a given flow rate were developed. Meanwhile, another device measures viscosity using the values of a flow rate ratio at a given boundary position [22]. Another group proposed a method of determining a flow rate ratio at the moment of a reverse flow occurring on account of the hydrodynamic balancing in a junction channel [23,24].…”

Section: Introductionmentioning

confidence: 99%

Micro-Viscometer for Measuring Shear-Varying Blood Viscosity over a Wide-Ranging Shear Rate

Kim

Lee

Jee

et al. 2017

Sensors

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In this study, a micro-viscometer is developed for measuring shear-varying blood viscosity over a wide-ranging shear rate. The micro-viscometer consists of 10 microfluidic channel arrays, each of which has a different micro-channel width. The proposed design enables the retrieval of 10 different shear rates from a single flow rate, thereby enabling the measurement of shear-varying blood viscosity with a fixed flow rate condition. For this purpose, an optimal design that guarantees accurate viscosity measurement is selected from a parametric study. The functionality of the micro-viscometer is verified by both numerical and experimental studies. The proposed micro-viscometer shows 6.8% (numerical) and 5.3% (experimental) in relative error when compared to the result from a standard rotational viscometer. Moreover, a reliability test is performed by repeated measurement (N = 7), and the result shows 2.69 ± 2.19% for the mean relative error. Accurate viscosity measurements are performed on blood samples with variations in the hematocrit (35%, 45%, and 55%), which significantly influences blood viscosity. Since the blood viscosity correlated with various physical parameters of the blood, the micro-viscometer is anticipated to be a significant advancement for realization of blood on a chip.

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Microfluidic Rheometer for Characterization of Protein Unfolding and Aggregation in Microflows

Cited by 43 publications

References 26 publications

Optical imaging techniques in microfluidics and their applications

Optical imaging techniques in microfluidics and their applications

Microfluidic parallel circuit for measurement of hydraulic resistance

Micro-Viscometer for Measuring Shear-Varying Blood Viscosity over a Wide-Ranging Shear Rate

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