Microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles for finely manipulated drug release

Zhou, Jiayu; Zhai, Yishu; Xu, Jumei; Zhou, Tian; Chen, Lian

doi:10.1016/j.ijpharm.2020.120173

Cited by 27 publications

(20 citation statements)

References 40 publications

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“…The results showed that Korsmeyer-Peppas models had the highest correlation coefficient R 2 and thus showed the best fit with in vitro release data. Moreover, the n value was 0.76 (0.43< n < 0.85), indicating a non-Fick diffusion kinetics (Zhou et al., 2021 ). It could be concluded that the drug release mechanism was mainly affected by drug diffusion and skeleton erosion.…”

Section: Resultsmentioning

confidence: 99%

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo

Liu

Tan

et al. 2022

Drug Delivery

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Microspheres play an important role in controlling drug delivery and release rate accurately. To realize the sustainable release of insoluble small-molecule drugs, a new three-phase flow-focusing microfluidic device was developed to produce the drug-loaded sustained-release microspheres which were prepared with bicalutamide (BCS class-II) as the model drug and poly(lactide-co-glycolide) (PLGA) as the carrier material. Under optimized prescription conditions, the microspheres showed a smooth surface and uniform size of 51.33 μm with a CV value of 4.43%. Sustained-release microspheres had a releasing duration of around 40 days in vitro without any initial burst release. The drug release mechanism of the microspheres was drug diffusion and polymer erosion. Meanwhile, the drug release of microspheres in vivo could be up to 30 days. Briefly, the microfluidic device in this study provides a new solution for the preparation of sustained-release microspheres for insoluble small-molecule drugs. PLGA sustained-release microspheres developed by the microfluidic device have good application prospects in precise delivery and sustainable release of insoluble small-molecule drugs.

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Section: Resultsmentioning

confidence: 99%

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo

Liu

Tan

et al. 2022

Drug Delivery

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“…The sustained release performance of nanoparticles was measured using a RC1207DP dissolution tester (Tianjin, China) and ultraviolet spectrophotometer (UV spectrophotometer, T6, Pgeneral, Beijing, China) [ 28 , 29 ]. Firstly, 800 mL of phosphate buffer (pH = 7.4) was utilized as the dissolution media to ensure the internal environment.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid

Zhang

et al. 2021

Polymers

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Chitosan nanoparticles have been considered as potential candidates for drug loading/release in drug delivery systems. In this paper, nanoparticles (HACAFNP) loading adriamycin based on 2-hydroxypropyltrimethyl ammonium chloride chitosan grafting folic acid (HACF) were synthesized. The surface morphology of the novel nanoparticles was spherical or oval, and the nanoparticles exhibited a relatively small hydrodynamic diameter (85.6 ± 2.04 nm) and positive zeta potential (+21.06 ± 0.96 mV). The drug release of nanoparticles was assayed and represented a burst effect followed by a long-term steady release. Afterward, the antioxidant efficiencies of nanoparticles were assayed. In particular, the target nanoparticles exhibited significant enhancement in radical scavenging activities. Cytotoxicities against cancer cells (MCF-7, BGC-823, and HEPG-2) were estimated in vitro, and results showed nanoparticles inhibited the growth of cancer cells. It’s worth noting that the inhibition index of HACAFNP against BGC-823 cells was 71.19% with the sample concentration of 25 μg/mL, which was much higher than the inhibitory effect of ADM. It was demonstrated that the novel nanoparticles with dramatically enhanced biological activity, reduced cytotoxicity, and steady release could be used as the practical candidates for drug loading/release in a delivery system.

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“… 81 − 83 Morphology-focused carriers with uniform hollow structures need an hour to efficiently run a drug delivery system, and these materials have the potential to deliver the guest molecules in systems with minimum damage to human body cells. 84 − 86 Until now, polyphosphazene microspheres have been utilized for modern day drug delivery systems because they can provide the monodispersion in solutions carrying large amounts of guest molecules of the drugs. 80 , 87 − 89 The biocompatibility and biodegrability of cyclopolyphosphazene materials are well-known, and many research groups 87 , 90 have used these molecules as biomaterials.…”

Section: Applications Of the Cyclomatrix Type Of Polyphosphazenesmentioning

confidence: 99%

Phosphazene Cyclomatrix Network-Based Polymer: Chemistry, Synthesis, and Applications

et al. 2022

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Polyphosphazenes are an inorganic molecular hybrid family with multifunctional properties due to their wide range of organic substitutes. This review intends to propose the basics of the synthetic chemistry of polyphosphazene, describing for researchers outside the field the basic knowledge required to design and prepare polyphosphazenes with desired properties. A special emphasis is placed on recent advances in chemical synthesis, which allow not only the synthesis of polyphosphazenes with controlled molecular weights and polydispersities but also the synthesis of novel branched designs and block copolymers. We also investigated the synthesis of polyphosphazenes using various functional materials. This review aims to assist researchers in synthesizing their specific polyphosphazene material with unique property combinations, with the hope of stimulating further research and even more innovative applications for these highly interesting multifaceted materials.

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Microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles for finely manipulated drug release

Cited by 27 publications

References 40 publications

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo

PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo

Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid

Phosphazene Cyclomatrix Network-Based Polymer: Chemistry, Synthesis, and Applications

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