Microfluidic preparation of optical sensors for biomedical applications

Wang, Qiao; Wang, Chong; Yang, Xinyuan; Wang, Jiali; Zhang, Zhuohao; Shang, Luoran

doi:10.1002/smmd.20220027

Cited by 16 publications

(8 citation statements)

References 177 publications

(178 reference statements)

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“…Preparation of Highly Permeable Targeted Bone/Chondrocyte Mitochondrial Micro/Nano Hydrogel Microspheres (SCT-HA): The SCT-HA was prepared using a laboratory-made microfluidic device. [46] In the aqueous phase, SCT was mixed with a hydrogel solution containing AHAMA, SCT, and a photoinitiator. Meanwhile, Span 80 and paraffin oil were mixed in the oil phase, and this mixture was injected into the microfluidic device inlet using a syringe to control the flow rate between aqueous and oil phase.…”

Section: Methodsmentioning

confidence: 99%

Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres

Zuo,

Zhuang,

Yang

et al. 2023

Advanced Science

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Destruction of cartilage due to the abnormal remodeling of subchondral bone (SB) leads to osteoarthritis (OA), and restoring chondro‐bone metabolic homeostasis is the key to the treatment of OA. However, traditional intra‐articular injections for the treatment of OA cannot directly break through the cartilage barrier to reach SB. In this study, the hydrothermal method is used to synthesize ultra‐small size (≈5 nm) selenium‐doped carbon quantum dots (Se‐CQDs, SC), which conjugated with triphenylphosphine (TPP) to create TPP‐Se‐CQDs (SCT). Further, SCT is dynamically complexed with hyaluronic acid modified with aldehyde and methacrylic anhydride (AHAMA) to construct highly permeable micro/nano hydrogel microspheres (SCT@AHAMA) for restoring chondro‐bone metabolic homeostasis. In vitro experiments confirmed that the selenium atoms scavenged reactive oxygen species (ROS) from the mitochondria of mononuclear macrophages, inhibited osteoclast differentiation and function, and suppressed early chondrocyte apoptosis to maintain a balance between cartilage matrix synthesis and catabolism. In vivo experiments further demonstrated that the delivery system inhibited osteoclastogenesis and H‐vessel invasion, thereby regulating the initiation and process of abnormal bone remodeling and inhibiting cartilage degeneration in SB. In conclusion, the micro/nano hydrogel microspheres based on ultra‐small quantum dots facilitate the efficient penetration of articular SB and regulate chondro‐bone metabolism for OA treatment.

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Section: Methodsmentioning

confidence: 99%

Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres

Zuo,

Zhuang,

Yang

et al. 2023

Advanced Science

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“…Various strategies have been developed to improve the signal-to-noise ratio and lifetime of the indicators [113]. These strategies involve optimizing the substrate materials, their structural properties, and integration with supplementary materials [114,115]. Additionally, selecting the appropriate wavelength of the incident light is critical in enhancing the sensitivity of optical sensors.…”

Section: Challenges and Potential Solutionsmentioning

confidence: 99%

In situ biosensing technologies for an organ-on-a-chip

Kim,

Jin

et al. 2023

Biofabrication

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The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges accompanying in vivo experiments. Organoids and organs-on-chips have been developed to model the in vitro, real-time biological and physiological features of organs. Numerous studies have deployed these systems to assess the in vitro, real-time responses of an organ to external stimuli. Particularly, organs-on-chips can be most efficiently employed in pharmaceutical drug development to predict the responses of organs before approving such drugs. Furthermore, multi-organ-on-a-chip systems facilitate the close representations of the in vivo environment. In this review, we discuss the biosensing technology that facilitates the in situ, real-time measurements of organ responses as readouts on organ-on-a-chip systems, including multi-organ models. Notably, a human-on-a-chip system integrated with automated multi-sensing will be established by further advancing the development of chips, as well as their assessment techniques.

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“…[26][27][28] The monitoring method based on the optical principle has been widely used in the clinic. [29] Nearinfrared spectroscopy can detect tissues by measuring the scattering and absorption of near-infrared light. It has been widely used to monitor tissue oxygen saturation through the skin.…”

Section: Optical Sensorsmentioning

confidence: 99%

Implantable Sensors for Post‐Surgical Monitoring of Vascular Complications

Zhao,

Eid,

Zhang

et al. 2023

Advanced Sensor Research

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For surgeries involving vessel anastomosis, it is critical to ensure fluent blood flow and to monitor the occurrence of vascular complications. However, the current clinical methods are ineffective in achieving direct, continuous, and accurate monitoring. At present, implantable sensors are widely used and explored in various biomedical applications, including cardiovascular disease, neurological disorders, cancer treatment, and health monitoring. They can be easily placed during surgical procedures and offer irreplaceable advantages including directness, continuity, and higher accuracy of monitoring. Based on this, the types of implantable sensors for vascular monitoring are reviewed, and some preclinical research advances which are expected to provide promising methods for post‐surgical vascular complications are discussed. In the end, the future perspectives of the research of implantable sensors for post‐surgical monitoring are put forward. It is believed that implantable sensors hold great promise in clinical translation, providing physicians with more accurate, continuous, and real‐time monitoring results, helping to improve surgical success and patient outcomes.

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Microfluidic preparation of optical sensors for biomedical applications

Cited by 16 publications

References 177 publications

Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres

Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres

In situ biosensing technologies for an organ-on-a-chip

Implantable Sensors for Post‐Surgical Monitoring of Vascular Complications

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